Nrf2 Activation With CDDO-Methyl Promotes Beneficial and Deleterious Clinical Effects in Transgenic Mice With Sickle Cell Anemia

Activation of Nrf2, a major transcription factor that drives the antioxidant defense system, is an emerging therapeutic strategy in Sickle Cell Disease (SCD). In this study, transgenic Sickle Cell Anemia mice (SS mice) treated with CDDO-Methyl (CDDO-Me), a potent Nrf2 activator, showed reduced progr...

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Detalles Bibliográficos
Autores principales: Ihunnah, Chibueze A., Ghosh, Samit, Hahn, Scott, Straub, Adam C., Ofori-Acquah, Solomon F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127300/
https://www.ncbi.nlm.nih.gov/pubmed/35620281
http://dx.doi.org/10.3389/fphar.2022.880834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127300/
https://www.ncbi.nlm.nih.gov/pubmed/35620281
http://dx.doi.org/10.3389/fphar.2022.880834

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