The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by α-secretase ADAM10

Neurotoxic amyloid β-peptides are thought to be a causative agent of Alzheimer’s disease in humans. The production of amyloid β-peptides from amyloid precursor protein (APP) could be diminished by enhancing α-processing; however, the physical interactions between APP and α-secretases are not well un...

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Detalles Bibliográficos
Autores principales: Hitschler, Lisa, Lang, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127328/
https://www.ncbi.nlm.nih.gov/pubmed/35398353
http://dx.doi.org/10.1016/j.jbc.2022.101911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127328/
https://www.ncbi.nlm.nih.gov/pubmed/35398353
http://dx.doi.org/10.1016/j.jbc.2022.101911

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