Posttranslational regulation of mitochondrial frataxin and identification of compounds that increase frataxin levels in Friedreich’s ataxia

Friedreich’s ataxia (FRDA) is a degenerative disease caused by a decrease in the mitochondrial protein frataxin (Fxn), which is involved in iron–sulfur cluster (ISC) synthesis. Diminutions in Fxn result in decreased ISC synthesis, increased mitochondrial iron accumulation, and impaired mitochondrial...

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Detalles Bibliográficos
Autores principales: Hackett, Peter T., Jia, Xuan, Li, Liangtao, Ward, Diane M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127368/
https://www.ncbi.nlm.nih.gov/pubmed/35472330
http://dx.doi.org/10.1016/j.jbc.2022.101982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127368/
https://www.ncbi.nlm.nih.gov/pubmed/35472330
http://dx.doi.org/10.1016/j.jbc.2022.101982

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