OGG1 Inhibition Triggers Synthetic Lethality and Enhances The Effect of PARP Inhibitor Olaparib in BRCA1-Deficient TNBC Cells

BACKGROUND: PARP1 plays a critical role in the base excision repair (BER) pathway, and PARP1 inhibition leads to specific cell death, through a synthetic lethal interaction, in the context of BRCA1/2 deficiency. To date, up to five different PARP inhibitors (PARPi), have been approved, nevertheless,...

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Detalles Bibliográficos
Autores principales: Baquero, Juan Miguel, Marchena-Perea, Erik, Mirabet, Rocío, Torres-Ruiz, Raúl, Blanco-Aparicio, Carmen, Rodríguez-Perales, Sandra, Helleday, Thomas, Benítez-Buelga, Carlos, Benítez, Javier, Osorio, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127384/
https://www.ncbi.nlm.nih.gov/pubmed/35619904
http://dx.doi.org/10.3389/fonc.2022.888810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127384/
https://www.ncbi.nlm.nih.gov/pubmed/35619904
http://dx.doi.org/10.3389/fonc.2022.888810

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