Combining SJ733, an oral ATP4 inhibitor of Plasmodium falciparum, with the pharmacokinetic enhancer cobicistat: An innovative approach in antimalarial drug development

BACKGROUND: SJ733, a newly developed inhibitor of P. falciparum ATP4, has a favorable safety profile and rapid antiparasitic effect but insufficient duration to deliver a single-dose cure of malaria. We investigated the safety, tolerability, and pharmacokinetics of a multidose SJ733 regimen and a si...

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Detalles Bibliográficos
Autores principales: Gaur, Aditya H., Panetta, John C., Smith, Amber M., Dallas, Ronald H., Freeman, Burgess B., Stewart, Tracy B., Tang, Li, John, Elizabeth, Branum, Kristen C., Patel, Nehali D., Ost, Shelley, Heine, Ryan N., Richardson, Julie L., Hammill, Jared T., Bebrevska, Lidiya, Gusovsky, Fabian, Maki, Noritsugu, Yanagi, Toshiharu, Flynn, Patricia M., McCarthy, James S., Chalon, Stephan, Guy, R. Kiplin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127571/
https://www.ncbi.nlm.nih.gov/pubmed/35598441
http://dx.doi.org/10.1016/j.ebiom.2022.104065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127571/
https://www.ncbi.nlm.nih.gov/pubmed/35598441
http://dx.doi.org/10.1016/j.ebiom.2022.104065

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