Cargando…

Combining SJ733, an oral ATP4 inhibitor of Plasmodium falciparum, with the pharmacokinetic enhancer cobicistat: An innovative approach in antimalarial drug development

BACKGROUND: SJ733, a newly developed inhibitor of P. falciparum ATP4, has a favorable safety profile and rapid antiparasitic effect but insufficient duration to deliver a single-dose cure of malaria. We investigated the safety, tolerability, and pharmacokinetics of a multidose SJ733 regimen and a si...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gaur, Aditya H., Panetta, John C., Smith, Amber M., Dallas, Ronald H., Freeman, Burgess B., Stewart, Tracy B., Tang, Li, John, Elizabeth, Branum, Kristen C., Patel, Nehali D., Ost, Shelley, Heine, Ryan N., Richardson, Julie L., Hammill, Jared T., Bebrevska, Lidiya, Gusovsky, Fabian, Maki, Noritsugu, Yanagi, Toshiharu, Flynn, Patricia M., McCarthy, James S., Chalon, Stephan, Guy, R. Kiplin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127571/ https://www.ncbi.nlm.nih.gov/pubmed/35598441 http://dx.doi.org/10.1016/j.ebiom.2022.104065

Ejemplares similares

Similarly efficacious anti-malarial drugs SJ733 and pyronaridine differ in their ability to remove circulating parasites in mice
por: SheelaNair, Arya, et al.
Publicado: (2022)

Plasmid-free CRISPR/Cas9 genome editing in Plasmodium falciparum confirms mutations conferring resistance to the dihydroisoquinolone clinical candidate SJ733
por: Crawford, Emily D., et al.
Publicado: (2017)

Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study
por: McCarthy, James S, et al.
Publicado: (2017)

Complete Draft Genome Sequence of Escherichia coli JF733
por: Kleiner, Gabriele R. M., et al.
Publicado: (2016)

On the Mechanism of Action of SJ-172550 in Inhibiting the Interaction of MDM4 and p53
por: Bista, Michal, et al.
Publicado: (2012)

Félix Restrepo, S.J. /
por: Cacua Prada, Antonio
Publicado: (1997)

Evaluating the role of atazanavir/cobicistat and darunavir/cobicistat fixed-dose combinations for the treatment of HIV-1 infection
por: Crutchley, Rustin D, et al.
Publicado: (2016)

$D_{sJ}^{(*)}$ Spectroscopy at LHCb
por: Ravina, Baptiste
Publicado: (2015)

Pascual Diaz, S.J., : el arzobispo mártir
por: Correa, Eduardo J.
Publicado: (1945)

733 Vancomycin-Resistant Enterococcus (VRE) faecium Bloodstream Infections and Mortality
por: Suleyman, Geehan, et al.
Publicado: (2014)

The NK1 antagonist L-733,060 facilitates sequence learning
por: Favila, Natalia, et al.
Publicado: (2023)

Safety and Efficacy of Lomitapide in Japanese Patients with Homozygous Familial Hypercholesterolemia (HoFH): Results from the AEGR-733-301 Long-Term Extension Study
por: Nohara, Atsushi, et al.
Publicado: (2019)

Archivo de Ignacio Ellacuría, S.J.
por: Reyes Ramírez, Rocío de los
Publicado: (2002)

Effect of leaf position and days post-infiltration on transient expression of colorectal cancer vaccine candidate proteins GA733-Fc and GA733-FcK in Nicotiana benthamiana plant
por: Kim, Kibum, et al.
Publicado: (2021)

Cobicistat/darunavir/cobicistat/darunavir/emtricitabine/tenofovir-alafenamide/darunavir/ritonavir: Various toxicities and off-label use: 9 case reports
Publicado: (2020)

SUN-733 Analysis of Divergent Long Noncoding RNAs in Estrogen-Regulated Transcription
por: Lee, Debra, et al.
Publicado: (2020)

The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation
por: Alao, John P, et al.
Publicado: (2009)

Francisco Xavier Clavigero, SJ : ilustre universitario constructor de la patria mexicana /
por: Maneiro, Juan Luis, 1744-1802
Publicado: (2004)

Anticancer Properties of Distinct Antimalarial Drug Classes
por: Hooft van Huijsduijnen, Rob, et al.
Publicado: (2013)

Predicting Human Age with Bloodstains by sjTREC Quantification
por: Ou, Xue-ling, et al.
Publicado: (2012)

SAT331 A Case Of Iatrogenic Cushing’s Syndrome Due To The Concomitant Use Of Cobicistat With An Inhaled Glucocorticoid Followed By Adrenal Insufficiency Upon Discontinuation Of Cobicistat
por: Noor, Laila, et al.
Publicado: (2023)

Optimization of the human colorectal carcinoma antigen GA733-2 production in tobacco plants
por: Park, Se Hee, et al.
Publicado: (2021)

Clonal distribution of vancomycin‐resistant Enterococcus faecium in Turkey and the new singleton ST733
por: Erdem, Fatma, et al.
Publicado: (2020)

733 Development of TeleBurn Utilizing Hospital Based EMR and Stroke Robot Photography
por: Bernal, Nicole, et al.
Publicado: (2023)

Antiviral Activity and Safety of Darunavir/Cobicistat for the Treatment of COVID-19
por: Chen, Jun, et al.
Publicado: (2020)

Rifabutin-Cobicistat Drug Interaction Resulting in Severe Bilateral Panuveitis
por: Toomey, Christopher B., et al.
Publicado: (2020)

Data on the stability of darunavir/cobicistat suspension after tablet manipulation
por: Zanon, D., et al.
Publicado: (2020)

Cobicistat: A case of mislabelled drug‐drug interaction risk?
por: Burger, David M., et al.
Publicado: (2020)

Ignacio Martin-Baró SJ : la psicología de la liberación como propuesta para los pueblos latinoamericanos /
por: Jardinez Hernández, José Arturo
Publicado: (2006)

Combined IL-12 Plasmid and Recombinant SjGST Enhance the Protective and Anti-pathology Effect of SjGST DNA Vaccine Against Schistosoma japonicum
por: Cheng, Po-Ching, et al.
Publicado: (2016)

Prime-Boost Vaccine Regimen for SjTPI and SjC23 Schistosome Vaccines, Increases Efficacy in Water Buffalo in a Field Trial in China
por: Da'Dara, Akram A., et al.
Publicado: (2019)

Small molecule SJ572946 activates BAK to initiate apoptosis
por: Sekar, Giridhar, et al.
Publicado: (2022)

TAK-733 inhibits inflammatory neointimal formation by suppressing proliferation, migration, and inflammation in vitro and in vivo
por: Park, Jun-Hee, et al.
Publicado: (2018)

The Ethnic and Geographical Distribution of Fabella: A Systematic Review and Meta-Analysis of 34,733 Knees
por: Asghar, Adil, et al.
Publicado: (2021)

733 Massive Burn Injuries: Characteristics, Treatment Strategies and Outcomes from a Single Institution
por: Heard, Jason, et al.
Publicado: (2022)

Pharmacokinetics of Temsavir, the Active Moiety of the HIV-1 Attachment Inhibitor Prodrug, Fostemsavir, Coadministered with Cobicistat, Etravirine, Darunavir/Cobicistat, or Darunavir/Ritonavir with or without Etravirine in Healthy Participants
por: Moore, Katy, et al.
Publicado: (2022)

Chemotaxis of Burkholderia sp. Strain SJ98 towards chloronitroaromatic compounds that it can metabolise
por: Pandey, Janmejay, et al.
Publicado: (2012)

A Single-Dose Combination Study with the Experimental Antimalarials Artefenomel and DSM265 To Determine Safety and Antimalarial Activity against Blood-Stage Plasmodium falciparum in Healthy Volunteers
por: McCarthy, James S., et al.
Publicado: (2019)

Clinical use of cobicistat as a pharmacoenhancer of human immunodeficiency virus therapy
por: von Hentig, Nils
Publicado: (2015)

Rationale and clinical utility of the darunavir–cobicistat combination in the treatment of HIV/AIDS
por: Putcharoen, Opass, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_11c7f0ghaug5mo2qelb7m1cng7