Cargando…

Sex-specific lipid dysregulation in the Abca7 knockout mouse brain

Alzheimer’s disease is a devastating neurodegenerative disease that affects more women than men. The pathomechanism underlying the sex disparity, especially in the brain, is unclear. ABCA7 is one of the strongest susceptibility genes for Alzheimer’s disease. It mediates the transport of lipids acros...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fu, YuHong, He, Ying, Phan, Katherine, Pickford, Russell, Kim, Young-Bum, Dzamko, Nicolas, Halliday, Glenda M., Kim, Woojin Scott
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127619/ https://www.ncbi.nlm.nih.gov/pubmed/35620166 http://dx.doi.org/10.1093/braincomms/fcac120

Ejemplares similares

Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain
por: Fu, YuHong, et al.
Publicado: (2022)

Multiple pathways of lipid dysregulation in amyotrophic lateral sclerosis
por: Phan, Katherine, et al.
Publicado: (2022)

Lipid pathway dysfunction is prevalent in patients with Parkinson’s disease
por: Galper, Jasmin, et al.
Publicado: (2022)

Deletion of Alzheimer’s Disease Risk Gene ABCA7 Alters White Adipose Tissue Development and Leptin Levels
por: Bhatia, Surabhi, et al.
Publicado: (2017)

Increased VLCFA-lipids and ELOVL4 underlie neurodegeneration in frontotemporal dementia
por: He, Ying, et al.
Publicado: (2021)

Uncovering pathophysiological changes in frontotemporal dementia using serum lipids
por: Phan, Katherine, et al.
Publicado: (2020)

Comparison of Different Platform Immunoassays for the Measurement of Plasma Alpha-Synuclein in Parkinson’s Disease Patients
por: Youssef, Priscilla, et al.
Publicado: (2021)

LRRK2 and Lipid Pathways: Implications for Parkinson’s Disease
por: Galper, Jasmin, et al.
Publicado: (2022)

Role of Abca7 in Mouse Behaviours Relevant to Neurodegenerative Diseases
por: Logge, Warren, et al.
Publicado: (2012)

Reduced glucocerebrosidase activity in monocytes from patients with Parkinson’s disease
por: Atashrazm, Farzaneh, et al.
Publicado: (2018)

ATP-binding cassette transporter expression is widely dysregulated in frontotemporal dementia with TDP-43 inclusions
por: Katzeff, Jared S., et al.
Publicado: (2022)

Live cell in situ lysosomal GCase activity correlates to alpha-synuclein levels in human differentiated neurons with LRRK2 and GBA1 mutations
por: Labrador-Garrido, Adahir, et al.
Publicado: (2023)

Evaluation of plasma levels of NFL, GFAP, UCHL1 and tau as Parkinson's disease biomarkers using multiplexed single molecule counting
por: Youssef, Priscilla, et al.
Publicado: (2023)

Pathological manifestation of human endogenous retrovirus K in frontotemporal dementia
por: Phan, Katherine, et al.
Publicado: (2021)

A small molecule toll-like receptor antagonist rescues α-synuclein fibril pathology
por: Chedid, Jessica, et al.
Publicado: (2022)

Parkinson’s disease-implicated kinases in the brain; insights into disease pathogenesis
por: Dzamko, Nicolas, et al.
Publicado: (2014)

Cross-examining candidate genes implicated in multiple system atrophy
por: Katzeff, Jared S., et al.
Publicado: (2019)

Lipid dysfunction and pathogenesis of multiple system atrophy
por: Bleasel, Jonathan M, et al.
Publicado: (2014)

Effects of Deletion of Macrophage ABCA7 on Lipid Metabolism and the Development of Atherosclerosis in the Presence and Absence of ABCA1
por: Meurs, Illiana, et al.
Publicado: (2012)

Parkinson’s progression prediction using machine learning and serum cytokines
por: Ahmadi Rastegar, Diba, et al.
Publicado: (2019)

Correction: Effects of Deletion of Macrophage ABCA7 on Lipid Metabolism and the Development of Atherosclerosis in the Presence and Absence of ABCA1
por: Meurs, Illiana, et al.
Publicado: (2012)

Toll-like receptor 2 is increased in neurons in Parkinson’s disease brain and may contribute to alpha-synuclein pathology
por: Dzamko, Nicolas, et al.
Publicado: (2016)

Lipidomics Analysis of Behavioral Variant Frontotemporal Dementia: A Scope for Biomarker Development
por: Kim, Woojin Scott, et al.
Publicado: (2018)

Dysregulated expression of lipid storage and membrane dynamics factors in Tia1 knockout mouse nervous tissue
por: Heck, Melanie Vanessa, et al.
Publicado: (2014)

Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice
por: Zhao, Ye, et al.
Publicado: (2018)

Leukocyte ABCA1 Remains Atheroprotective in Splenectomized LDL Receptor Knockout Mice
por: Lammers, Bart, et al.
Publicado: (2012)

Abca7 deletion does not affect adult neurogenesis in the mouse
por: Li, Hongyun, et al.
Publicado: (2016)

Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy
por: Don, Anthony S, et al.
Publicado: (2014)

Elevation in Sphingomyelin Synthase Activity Is Associated with Increases in Amyloid-Beta Peptide Generation
por: Hsiao, Jen-Hsiang T., et al.
Publicado: (2013)

Alpha-synuclein biology in Lewy body diseases
por: Kim, Woojin Scott, et al.
Publicado: (2014)

Animal modeling an oligodendrogliopathy – multiple system atrophy
por: Bleasel, Jonathan M., et al.
Publicado: (2016)

Exploring Myelin Dysfunction in Multiple System Atrophy
por: Wong, Joanna H., et al.
Publicado: (2014)

α-Synuclein Regulates Neuronal Cholesterol Efflux
por: Hsiao, Jen-Hsiang T., et al.
Publicado: (2017)

ATP-binding cassette transporters as possible targets for the intervention of neurodegenerative diseases
por: Lok, Hiu Chuen, et al.
Publicado: (2023)

A Mouse Model of Harlequin Ichthyosis Delineates a Key Role for Abca12 in Lipid Homeostasis
por: Smyth, Ian, et al.
Publicado: (2008)

Altered High Density Lipoprotein Composition in Behavioral Variant Frontotemporal Dementia
por: Kim, Woojin Scott, et al.
Publicado: (2018)

Potentiation of ABCA3 lipid transport function by ivacaftor and genistein
por: Kinting, Susanna, et al.
Publicado: (2019)

Correction: A Mouse Model of Harlequin Ichthyosis Delineates a Key Role for Abca12 in Lipid Homeostasis
por: Smyth, Ian, et al.
Publicado: (2008)

Elevated GRO-α and IL-18 in serum and brain implicate the NLRP3 inflammasome in frontotemporal dementia
por: Lok, Hiu Chuen, et al.
Publicado: (2023)

Lipid metabolism is dysregulated in a mouse model of diabetes
por: Furse, Samuel
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_pp27eqcnsn9s863cohpoojr4pi