Cargando…

Chemical Proteomics Reveals Off-Targets of the Anandamide Reuptake Inhibitor WOBE437

[Image: see text] Anandamide or N-arachidonoylethanolamine (AEA) is a signaling lipid that modulates neurotransmitter release via activation of the type 1 cannabinoid receptor (CB(1)R) in the brain. Termination of anandamide signaling is thought to be mediated via a facilitated cellular reuptake pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gagestein, Berend, Stevens, Anna F., Fazio, Domenico, Florea, Bogdan I., van der Wel, Tom, Bakker, Alexander T., Fezza, Filomena, Dulk, Hans den, Overkleeft, Herman S., Maccarrone, Mauro, van der Stelt, Mario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127799/ https://www.ncbi.nlm.nih.gov/pubmed/35482948 http://dx.doi.org/10.1021/acschembio.2c00122

Ejemplares similares

Selective Endocannabinoid Reuptake Inhibitor WOBE437 Reduces Disease Progression in a Mouse Model of Multiple Sclerosis
por: Reynoso-Moreno, Ines, et al.
Publicado: (2021)

The Endocannabinoid Reuptake Inhibitor WOBE437 Is Orally Bioavailable and Exerts Indirect Polypharmacological Effects via Different Endocannabinoid Receptors
por: Reynoso-Moreno, Inés, et al.
Publicado: (2018)

Olaparib‐Based Photoaffinity Probes for PARP‐1 Detection in Living Cells
por: Voorneveld, Jim, et al.
Publicado: (2020)

Identification of α,β-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells
por: van Esbroeck, Annelot C. M., et al.
Publicado: (2019)

Comparative Photoaffinity Profiling of Omega-3 Signaling Lipid Probes Reveals Prostaglandin Reductase 1 as a Metabolic Hub in Human Macrophages
por: Gagestein, Berend, et al.
Publicado: (2022)

ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction
por: Baggelaar, Marc P., et al.
Publicado: (2019)

Live‐Cell Imaging of Sterculic Acid—a Naturally Occurring 1,2‐Cyclopropene Fatty Acid—by Bioorthogonal Reaction with Turn‐On Tetrazine‐Fluorophore Conjugates
por: Bertheussen, Kristine, et al.
Publicado: (2022)

ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction
por: Baggelaar, Marc P., et al.
Publicado: (2019)

Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis
por: van der Wel, Tom, et al.
Publicado: (2020)

Activity-Based Protein Profiling Identifies α-Ketoamides as Inhibitors for Phospholipase A2 Group XVI
por: Zhou, Juan, et al.
Publicado: (2019)

Metabolism of the Endocannabinoid Anandamide: Open Questions after 25 Years
por: Maccarrone, Mauro
Publicado: (2017)

Role of FAAH-Like Anandamide Transporter in Anandamide Inactivation
por: Leung, KwanNok, et al.
Publicado: (2013)

Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells
por: Koenders, Sebastiaan T. A., et al.
Publicado: (2019)

Effects of anandamide in migraine: data from an animal model
por: Greco, Rosaria, et al.
Publicado: (2011)

Quantification of anandamide content in animal cells and tissues: the normalization makes the difference
por: Maccarrone, Mauro, et al.
Publicado: (2002)

SAT437 Immunotherapy Induced Pituitary Apoplexy
por: Uddin, Ashraf, et al.
Publicado: (2023)

Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain
por: van Rooden, Eva J., et al.
Publicado: (2018)

Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors
por: Deng, Hui, et al.
Publicado: (2017)

Anandamide uptake by synaptosomes from human, mouse and rat brain: inhibition by glutamine and glutamate
por: Battista, Natalia, et al.
Publicado: (2002)

Stage-variations of anandamide hydrolase activity in the mouse uterus during the natural oestrus cycle
por: Klinger, Francesca G, et al.
Publicado: (2006)

CCNP Voice CVoice 642-437: quick reference
por: Sauer, Toby, et al.
Publicado: (2011)

SUN-437 Central Adrenal Insufficiency Unmasked by Pregnancy
por: Araque, Katherine, et al.
Publicado: (2019)

MON-437 False Positive I-131 Uptake
por: Yadav, Pavan Rajendra, et al.
Publicado: (2020)

Antiviral Activity of CD437 Against Mumps Virus
por: Kato, Fumihiro, et al.
Publicado: (2021)

Correction to Lancet Neurol 2021; 20: 437–47
Publicado: (2021)

A novel inducible prophage from the mycosphere inhabitant Paraburkholderia terrae BS437
por: Pratama, Akbar Adjie, et al.
Publicado: (2017)

In Silico and In Vitro Analysis of Major Cannabis-Derived Compounds as Fatty Acid Amide Hydrolase Inhibitors
por: Criscuolo, Emanuele, et al.
Publicado: (2020)

437. Asymptomatic Healthcare Worker COVID-19 Testing Program
por: Horton, Lucy E, et al.
Publicado: (2020)

THU437 Oral Ulcers As A Clue To Bone Fragility
por: Sridhar, Sushrutha, et al.
Publicado: (2023)

Possible Anandamide and Palmitoylethanolamide involvement in human stroke
por: Naccarato, Marcello, et al.
Publicado: (2010)

Inactivation of Anandamide Signaling: A Continuing Debate
por: Khairy, Hesham, et al.
Publicado: (2010)

Anandamide inhibits breast tumor-induced angiogenesis
por: Picardi, P, et al.
Publicado: (2014)

Alterations in the Anandamide Metabolism in the Development of Neuropathic Pain
por: Malek, Natalia, et al.
Publicado: (2014)

The endocannabinoid anandamide is an airway relaxant in health and disease
por: Simon, Annika, et al.
Publicado: (2022)

Structure‐Based Design of Fluorogenic Substrates Selective for Human Proteasome Subunits
por: Maurits, Elmer, et al.
Publicado: (2020)

The Influence of Anandamide on the Anterior Pituitary Hormone Secretion in Ewes—Ex Vivo Study
por: Tomaszewska-Zaremba, Dorota, et al.
Publicado: (2020)

Effects of intracerebroventricular anandamide administration on feed intake and milk yield of dairy cows
por: Kuhla, Björn, et al.
Publicado: (2022)

Endocannabinoids, Related Compounds and Their Metabolic Routes
por: Fezza, Filomena, et al.
Publicado: (2014)

Scope and Limitations of Boron Fluorescent Complexes from Stable Nitrile Oxides in ABPP Assays
por: Moiola, Mattia, et al.
Publicado: (2019)

Antiemetic Prescription Fills in Pregnancy: A Drug Utilization Study Among 762,437 Pregnancies in Norway
por: van Gelder, Marleen M H J, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_21cbaqel74522rr90prc3fs1fs