RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer’s disease, and normative aging

BACKGROUND: Regulator of calcineurin 1 (RCAN1) is overexpressed in Down syndrome (DS), but RCAN1 levels are also increased in Alzheimer’s disease (AD) and normal aging. AD is highly comorbid among individuals with DS and is characterized in part by progressive neurodegeneration that resembles accele...

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Detalles Bibliográficos
Autores principales: Wong, Helen, Buck, Jordan M., Borski, Curtis, Pafford, Jessica T., Keller, Bailey N., Milstead, Ryan A., Hanson, Jessica L., Stitzel, Jerry A., Hoeffer, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128232/
https://www.ncbi.nlm.nih.gov/pubmed/35610565
http://dx.doi.org/10.1186/s11689-022-09444-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128232/
https://www.ncbi.nlm.nih.gov/pubmed/35610565
http://dx.doi.org/10.1186/s11689-022-09444-y

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