Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal

The essential pre-mRNA splicing factor U2AF2 (also called U2AF(65)) identifies polypyrimidine (Py) tract signals of nascent transcripts, despite length and sequence variations. Previous studies have shown that the U2AF2 RNA recognition motifs (RRM1 and RRM2) preferentially bind uridine-rich RNAs. No...

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Detalles Bibliográficos
Autores principales: Glasser, Eliezra, Maji, Debanjana, Biancon, Giulia, Puthenpeedikakkal, Anees Mohammed Keedakkatt, Cavender, Chapin E, Tebaldi, Toma, Jenkins, Jermaine L, Mathews, David H, Halene, Stephanie, Kielkopf, Clara L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128377/
https://www.ncbi.nlm.nih.gov/pubmed/35524551
http://dx.doi.org/10.1093/nar/gkac287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128377/
https://www.ncbi.nlm.nih.gov/pubmed/35524551
http://dx.doi.org/10.1093/nar/gkac287

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