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The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis
Atopic dermatitis (AD) is a chronic, or chronically relapsing, inflammatory skin disease associated with asthma and allergic rhinitis, and is dominated by Th2 cells. The co-stimulatory T-cell receptor OX40 and its ligand, OX40L, play a central role in the pathogenesis of AD, as their interactions ar...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Society for Publication of Acta Dermato-Venereologica
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128899/ https://www.ncbi.nlm.nih.gov/pubmed/32176307 http://dx.doi.org/10.2340/00015555-3452 |
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author | ELSNER, Julie Sophie Hohwü CARLSSON, Michael STOUGAARD, Julie Kristine NYGAARD, Uffe BUCHNER, Matthias FÖLSTER-HOLST, Regina HVID, Malene VESTERGAARD, Christian DELEURAN, Mette DELEURAN, Bent |
author_facet | ELSNER, Julie Sophie Hohwü CARLSSON, Michael STOUGAARD, Julie Kristine NYGAARD, Uffe BUCHNER, Matthias FÖLSTER-HOLST, Regina HVID, Malene VESTERGAARD, Christian DELEURAN, Mette DELEURAN, Bent |
author_sort | ELSNER, Julie Sophie Hohwü |
collection | PubMed |
description | Atopic dermatitis (AD) is a chronic, or chronically relapsing, inflammatory skin disease associated with asthma and allergic rhinitis, and is dominated by Th2 cells. The co-stimulatory T-cell receptor OX40 and its ligand, OX40L, play a central role in the pathogenesis of AD, as their interactions are crucial for the generation of T(H)2 memory cells. Using enzyme-linked immunoassay (ELISA) and flow cytometry on blood samples from patients with AD and healthy volunteers, this study shows that the serum level of soluble (s) OX40 is decreased in patients with AD, and the expression of OX40 by activated skin-homing CD4+ T cells is increased. This study further shows, using immunofluorescence on skin biopsies, that OX40+ and OX40L+ cells are co-located within the dermis, indicating local activity of OX40/OX40L. Serum levels of sOX40 were associated with atopic diseases and, together, these results support that the OX40 system is important for chronic inflammation in AD skin. |
format | Online Article Text |
id | pubmed-9128899 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Society for Publication of Acta Dermato-Venereologica |
record_format | MEDLINE/PubMed |
spelling | pubmed-91288992022-10-20 The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis ELSNER, Julie Sophie Hohwü CARLSSON, Michael STOUGAARD, Julie Kristine NYGAARD, Uffe BUCHNER, Matthias FÖLSTER-HOLST, Regina HVID, Malene VESTERGAARD, Christian DELEURAN, Mette DELEURAN, Bent Acta Derm Venereol Investigative Report Atopic dermatitis (AD) is a chronic, or chronically relapsing, inflammatory skin disease associated with asthma and allergic rhinitis, and is dominated by Th2 cells. The co-stimulatory T-cell receptor OX40 and its ligand, OX40L, play a central role in the pathogenesis of AD, as their interactions are crucial for the generation of T(H)2 memory cells. Using enzyme-linked immunoassay (ELISA) and flow cytometry on blood samples from patients with AD and healthy volunteers, this study shows that the serum level of soluble (s) OX40 is decreased in patients with AD, and the expression of OX40 by activated skin-homing CD4+ T cells is increased. This study further shows, using immunofluorescence on skin biopsies, that OX40+ and OX40L+ cells are co-located within the dermis, indicating local activity of OX40/OX40L. Serum levels of sOX40 were associated with atopic diseases and, together, these results support that the OX40 system is important for chronic inflammation in AD skin. Society for Publication of Acta Dermato-Venereologica 2020-03-31 /pmc/articles/PMC9128899/ /pubmed/32176307 http://dx.doi.org/10.2340/00015555-3452 Text en © 2020 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license |
spellingShingle | Investigative Report ELSNER, Julie Sophie Hohwü CARLSSON, Michael STOUGAARD, Julie Kristine NYGAARD, Uffe BUCHNER, Matthias FÖLSTER-HOLST, Regina HVID, Malene VESTERGAARD, Christian DELEURAN, Mette DELEURAN, Bent The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis |
title | The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis |
title_full | The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis |
title_fullStr | The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis |
title_full_unstemmed | The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis |
title_short | The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis |
title_sort | ox40 axis is associated with both systemic and local involvement in atopic dermatitis |
topic | Investigative Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128899/ https://www.ncbi.nlm.nih.gov/pubmed/32176307 http://dx.doi.org/10.2340/00015555-3452 |
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