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The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis

Atopic dermatitis (AD) is a chronic, or chronically relapsing, inflammatory skin disease associated with asthma and allergic rhinitis, and is dominated by Th2 cells. The co-stimulatory T-cell receptor OX40 and its ligand, OX40L, play a central role in the pathogenesis of AD, as their interactions ar...

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Autores principales: ELSNER, Julie Sophie Hohwü, CARLSSON, Michael, STOUGAARD, Julie Kristine, NYGAARD, Uffe, BUCHNER, Matthias, FÖLSTER-HOLST, Regina, HVID, Malene, VESTERGAARD, Christian, DELEURAN, Mette, DELEURAN, Bent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Publication of Acta Dermato-Venereologica 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128899/
https://www.ncbi.nlm.nih.gov/pubmed/32176307
http://dx.doi.org/10.2340/00015555-3452
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author ELSNER, Julie Sophie Hohwü
CARLSSON, Michael
STOUGAARD, Julie Kristine
NYGAARD, Uffe
BUCHNER, Matthias
FÖLSTER-HOLST, Regina
HVID, Malene
VESTERGAARD, Christian
DELEURAN, Mette
DELEURAN, Bent
author_facet ELSNER, Julie Sophie Hohwü
CARLSSON, Michael
STOUGAARD, Julie Kristine
NYGAARD, Uffe
BUCHNER, Matthias
FÖLSTER-HOLST, Regina
HVID, Malene
VESTERGAARD, Christian
DELEURAN, Mette
DELEURAN, Bent
author_sort ELSNER, Julie Sophie Hohwü
collection PubMed
description Atopic dermatitis (AD) is a chronic, or chronically relapsing, inflammatory skin disease associated with asthma and allergic rhinitis, and is dominated by Th2 cells. The co-stimulatory T-cell receptor OX40 and its ligand, OX40L, play a central role in the pathogenesis of AD, as their interactions are crucial for the generation of T(H)2 memory cells. Using enzyme-linked immunoassay (ELISA) and flow cytometry on blood samples from patients with AD and healthy volunteers, this study shows that the serum level of soluble (s) OX40 is decreased in patients with AD, and the expression of OX40 by activated skin-homing CD4+ T cells is increased. This study further shows, using immunofluorescence on skin biopsies, that OX40+ and OX40L+ cells are co-located within the dermis, indicating local activity of OX40/OX40L. Serum levels of sOX40 were associated with atopic diseases and, together, these results support that the OX40 system is important for chronic inflammation in AD skin.
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spelling pubmed-91288992022-10-20 The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis ELSNER, Julie Sophie Hohwü CARLSSON, Michael STOUGAARD, Julie Kristine NYGAARD, Uffe BUCHNER, Matthias FÖLSTER-HOLST, Regina HVID, Malene VESTERGAARD, Christian DELEURAN, Mette DELEURAN, Bent Acta Derm Venereol Investigative Report Atopic dermatitis (AD) is a chronic, or chronically relapsing, inflammatory skin disease associated with asthma and allergic rhinitis, and is dominated by Th2 cells. The co-stimulatory T-cell receptor OX40 and its ligand, OX40L, play a central role in the pathogenesis of AD, as their interactions are crucial for the generation of T(H)2 memory cells. Using enzyme-linked immunoassay (ELISA) and flow cytometry on blood samples from patients with AD and healthy volunteers, this study shows that the serum level of soluble (s) OX40 is decreased in patients with AD, and the expression of OX40 by activated skin-homing CD4+ T cells is increased. This study further shows, using immunofluorescence on skin biopsies, that OX40+ and OX40L+ cells are co-located within the dermis, indicating local activity of OX40/OX40L. Serum levels of sOX40 were associated with atopic diseases and, together, these results support that the OX40 system is important for chronic inflammation in AD skin. Society for Publication of Acta Dermato-Venereologica 2020-03-31 /pmc/articles/PMC9128899/ /pubmed/32176307 http://dx.doi.org/10.2340/00015555-3452 Text en © 2020 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license
spellingShingle Investigative Report
ELSNER, Julie Sophie Hohwü
CARLSSON, Michael
STOUGAARD, Julie Kristine
NYGAARD, Uffe
BUCHNER, Matthias
FÖLSTER-HOLST, Regina
HVID, Malene
VESTERGAARD, Christian
DELEURAN, Mette
DELEURAN, Bent
The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis
title The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis
title_full The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis
title_fullStr The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis
title_full_unstemmed The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis
title_short The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis
title_sort ox40 axis is associated with both systemic and local involvement in atopic dermatitis
topic Investigative Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128899/
https://www.ncbi.nlm.nih.gov/pubmed/32176307
http://dx.doi.org/10.2340/00015555-3452
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