Unusual mammalian usage of TGA stop codons reveals that sequence conservation need not imply purifying selection

The assumption that conservation of sequence implies the action of purifying selection is central to diverse methodologies to infer functional importance. GC-biased gene conversion (gBGC), a meiotic mismatch repair bias strongly favouring GC over AT, can in principle mimic the action of selection, t...

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Detalles Bibliográficos
Autores principales: Ho, Alexander Thomas, Hurst, Laurence Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129041/
https://www.ncbi.nlm.nih.gov/pubmed/35550630
http://dx.doi.org/10.1371/journal.pbio.3001588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129041/
https://www.ncbi.nlm.nih.gov/pubmed/35550630
http://dx.doi.org/10.1371/journal.pbio.3001588

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