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Unusual mammalian usage of TGA stop codons reveals that sequence conservation need not imply purifying selection
The assumption that conservation of sequence implies the action of purifying selection is central to diverse methodologies to infer functional importance. GC-biased gene conversion (gBGC), a meiotic mismatch repair bias strongly favouring GC over AT, can in principle mimic the action of selection, t...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129041/ https://www.ncbi.nlm.nih.gov/pubmed/35550630 http://dx.doi.org/10.1371/journal.pbio.3001588 |