Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients

Bipolar disorder (BD) is a psychiatric condition characterized by depressive and manic episodes that affect 2% of the world population. The first-line long-term treatment for mood stabilization is lithium (Li). Induced pluripotent stem cell modeling of BD using hippocampal dentate gyrus-like neurons...

Descripción completa

Detalles Bibliográficos
Autores principales: Santos, Renata, Linker, Sara B., Stern, Shani, Mendes, Ana P. D., Shokhirev, Maxim N., Erikson, Galina, Randolph-Moore, Lynne, Racha, Vipula, Kim, Yeni, Kelsoe, John R., Bang, Anne G., Alda, M., Marchetto, Maria C., Gage, Fred H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129103/
https://www.ncbi.nlm.nih.gov/pubmed/33398088
http://dx.doi.org/10.1038/s41380-020-00981-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129103/
https://www.ncbi.nlm.nih.gov/pubmed/33398088
http://dx.doi.org/10.1038/s41380-020-00981-3

Ejemplares similares