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Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients

Bipolar disorder (BD) is a psychiatric condition characterized by depressive and manic episodes that affect 2% of the world population. The first-line long-term treatment for mood stabilization is lithium (Li). Induced pluripotent stem cell modeling of BD using hippocampal dentate gyrus-like neurons...

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Detalles Bibliográficos
Autores principales:	Santos, Renata, Linker, Sara B., Stern, Shani, Mendes, Ana P. D., Shokhirev, Maxim N., Erikson, Galina, Randolph-Moore, Lynne, Racha, Vipula, Kim, Yeni, Kelsoe, John R., Bang, Anne G., Alda, M., Marchetto, Maria C., Gage, Fred H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129103/ https://www.ncbi.nlm.nih.gov/pubmed/33398088 http://dx.doi.org/10.1038/s41380-020-00981-3

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