Design, synthesis and evaluation of amino-3,5-dicyanopyridines and thieno[2,3-b]pyridines as ligands of adenosine A(1) receptors for the potential treatment of epilepsy

Due to the implication of adenosine in seizure suppression, adenosine-based therapies such as adenosine receptor (AR) agonists have been investigated. This study aimed at investigating thieno[2,3-b]pyridine derivatives as non-nucleoside A(1) agonists that could be used in pharmaco-resistant epilepsy...

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Detalles Bibliográficos
Autores principales: Nkomba, Gaofenngwe, Terre’Blanche, Gisella, Janse van Rensburg, Helena D., Legoabe, Lesetja J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129901/
https://www.ncbi.nlm.nih.gov/pubmed/35634433
http://dx.doi.org/10.1007/s00044-022-02908-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129901/
https://www.ncbi.nlm.nih.gov/pubmed/35634433
http://dx.doi.org/10.1007/s00044-022-02908-9

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