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Design, synthesis and evaluation of amino-3,5-dicyanopyridines and thieno[2,3-b]pyridines as ligands of adenosine A(1) receptors for the potential treatment of epilepsy

Due to the implication of adenosine in seizure suppression, adenosine-based therapies such as adenosine receptor (AR) agonists have been investigated. This study aimed at investigating thieno[2,3-b]pyridine derivatives as non-nucleoside A(1) agonists that could be used in pharmaco-resistant epilepsy...

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Detalles Bibliográficos
Autores principales:	Nkomba, Gaofenngwe, Terre’Blanche, Gisella, Janse van Rensburg, Helena D., Legoabe, Lesetja J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129901/ https://www.ncbi.nlm.nih.gov/pubmed/35634433 http://dx.doi.org/10.1007/s00044-022-02908-9

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