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Differential effects of acute and chronic antagonist and an irreversible antagonist treatment on cocaine self-administration behavior in rats
According to pharmacological theory, the magnitude of an agonist-induced response is related to the number of receptors occupied. If there is a receptor reserve, when the number of receptors is altered the fractional occupancy required to maintain this set number of receptors will change. Therefore,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130121/ https://www.ncbi.nlm.nih.gov/pubmed/35610298 http://dx.doi.org/10.1038/s41598-022-12798-x |