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GSDMEa-mediated pyroptosis is bi-directionally regulated by caspase and required for effective bacterial clearance in teleost

Gasdermin (GSDM) is a family of pore-forming proteins that, after cleavage by caspase (CASP), induce a type of programmed necrotic cell death called pyroptosis. Gasdermin E (GSDME) is the only pyroptosis-inducing member of the GSDM family existing in teleost. To date, the regulation and function of...

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Detalles Bibliográficos
Autores principales: Xu, Hang, Jiang, Shuai, Yu, Chao, Yuan, Zihao, Sun, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130220/
https://www.ncbi.nlm.nih.gov/pubmed/35610210
http://dx.doi.org/10.1038/s41419-022-04896-5