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An inhibitor of RORγ for chronic pulmonary obstructive disease treatment

The role of RORγ as a transcription factor for Th17 cell differentiation and thereby regulation of IL-17 levels is well known. Increased RORγ expression along with IL-17A levels was observed in animal models, immune cells and BAL fluid of COPD patients. Increased IL-17A levels in severe COPD patient...

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Detalles Bibliográficos
Autores principales: Desai, Harshada, Marathe, Megha, Potdar, Varada, Tiwari, Prabhakar, Joshi, Ashwini, Kadam, Sheetal R., Joshi, Arti Rajesh, Kulkarni, Abhay, Bhosale, Vikram, Hadambar, Avinash, Lodhiya, Bhavik, Udupa, Venkatesha, Behera, Dayanidhi, Chaudhari, Sachin S., Das, Sanjib, Bajpai, Malini, Gowda, Nagaraj, Iyer, Pravin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130233/
https://www.ncbi.nlm.nih.gov/pubmed/35610240
http://dx.doi.org/10.1038/s41598-022-12251-z