Development of a stable antibody production system utilizing an Hspa5 promoter in CHO cells

Chinese hamster ovary (CHO) cells are widely used for manufacturing antibody drugs. We attempted to clone a novel high-expression promoter for producing monoclonal antibodies (mAbs) based on transcriptome analysis to enhance the transcriptional abundance of mAb genes. The efficacy of conventional pr...

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Detalles Bibliográficos
Autores principales: Tanemura, Hiroki, Masuda, Kenji, Okumura, Takeshi, Takagi, Eri, Kajihara, Daisuke, Kakihara, Hirofumi, Nonaka, Koichi, Ushioda, Ryo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130236/
https://www.ncbi.nlm.nih.gov/pubmed/35610229
http://dx.doi.org/10.1038/s41598-022-11342-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130236/
https://www.ncbi.nlm.nih.gov/pubmed/35610229
http://dx.doi.org/10.1038/s41598-022-11342-1

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