Crystal structure of ultra-humanized anti-pTau Fab reveals how germline substitutions humanize CDRs without loss of binding’

Administration of therapeutic antibodies can elicit adverse immune responses in patients through the generation of anti-drug antibodies that, in turn, reduce the efficacy of the therapeutic. Removal of foreign amino acid content by humanization can lower the immunogenic risk of the therapeutic mAb....

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Detalles Bibliográficos
Autores principales: Brinth, Alette R., Svenson, Kristine, Mosyak, Lidia, Cunningham, Orla, Hickling, Timothy, Lambert, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130293/
https://www.ncbi.nlm.nih.gov/pubmed/35610505
http://dx.doi.org/10.1038/s41598-022-12838-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130293/
https://www.ncbi.nlm.nih.gov/pubmed/35610505
http://dx.doi.org/10.1038/s41598-022-12838-6

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