Pyruvate kinase M1 regulates butyrate metabolism in cancerous colonocytes

Colorectal cancer (CRC) cells shift metabolism toward aerobic glycolysis and away from using oxidative substrates such as butyrate. Pyruvate kinase M1/2 (PKM) is an enzyme that catalyzes the last step in glycolysis, which converts phosphoenolpyruvate to pyruvate. M1 and M2 are alternatively spliced...

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Detalles Bibliográficos
Autores principales: Park, Bohye, Kim, Ji Yeon, Riffey, Olivia F., Dowker-Key, Presley, Bruckbauer, Antje, McLoughlin, James, Bettaieb, Ahmed, Donohoe, Dallas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130307/
https://www.ncbi.nlm.nih.gov/pubmed/35610475
http://dx.doi.org/10.1038/s41598-022-12827-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130307/
https://www.ncbi.nlm.nih.gov/pubmed/35610475
http://dx.doi.org/10.1038/s41598-022-12827-9

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