Cargando…

Pyruvate kinase M1 regulates butyrate metabolism in cancerous colonocytes

Colorectal cancer (CRC) cells shift metabolism toward aerobic glycolysis and away from using oxidative substrates such as butyrate. Pyruvate kinase M1/2 (PKM) is an enzyme that catalyzes the last step in glycolysis, which converts phosphoenolpyruvate to pyruvate. M1 and M2 are alternatively spliced...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Bohye, Kim, Ji Yeon, Riffey, Olivia F., Dowker-Key, Presley, Bruckbauer, Antje, McLoughlin, James, Bettaieb, Ahmed, Donohoe, Dallas R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130307/ https://www.ncbi.nlm.nih.gov/pubmed/35610475 http://dx.doi.org/10.1038/s41598-022-12827-9

Ejemplares similares

Butyrate Alters Pyruvate Flux and Induces Lipid Accumulation in Cultured Colonocytes
por: Bekebrede, Anna F., et al.
Publicado: (2021)

Microbial Regulation of Glucose Metabolism and Cell-Cycle Progression in Mammalian Colonocytes
por: Donohoe, Dallas R., et al.
Publicado: (2012)

Butyrate decreases its own oxidation in colorectal cancer cells through inhibition of histone deacetylases
por: Han, Anna, et al.
Publicado: (2018)

Interaction between Butyrate and Tumor Necrosis Factor α in Primary Rat Colonocytes
por: Souders, Christopher L., et al.
Publicado: (2023)

Hypoxia promotes proliferation and inhibits myogenesis in broiler satellite cells
por: Jung, Usuk, et al.
Publicado: (2023)

Phytate and Butyrate Differently Influence the Proliferation, Apoptosis and Survival Pathways in Human Cancer and Healthy Colonocytes
por: Markiewicz, Lidia Hanna, et al.
Publicado: (2021)

Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury
por: Gill, Nicholas B., et al.
Publicado: (2023)

Podocyte specific deletion of PKM2 ameliorates LPS-induced podocyte injury through beta-catenin
por: Alquraishi, Mohammed, et al.
Publicado: (2022)

Microbial Oncotarget: Bacterial-Produced Butyrate, Chemoprevention and Warburg Effect
por: Donohoe, Dallas R., et al.
Publicado: (2013)

Zinc Sensing Receptor Signaling, Mediated by GPR39, Reduces Butyrate-Induced Cell Death in HT29 Colonocytes via Upregulation of Clusterin
por: Cohen, Limor, et al.
Publicado: (2012)

Effects of DCA on Cell Cycle Proteins in Colonocytes
por: Ha, Yun-Hyung, et al.
Publicado: (2010)

Isoform Switch of Pyruvate Kinase M1 Indeed Occurs but Not to Pyruvate Kinase M2 in Human Tumorigenesis
por: Zhan, Cheng, et al.
Publicado: (2015)

Induction of a chemoattractant transcriptional response by a Campylobacter jejuni boiled cell extract in colonocytes
por: Mellits, Kenneth H, et al.
Publicado: (2009)

Protein Stability of Pyruvate Kinase Isozyme M2 Is Mediated by HAUSP
por: Choi, Hae-Seul, et al.
Publicado: (2020)

Protein kinase function of pyruvate kinase M2 and cancer
por: Chen, Xun, et al.
Publicado: (2020)

Keratins modulate colonocyte electrolyte transport via protein mistargeting
por: Toivola, Diana M., et al.
Publicado: (2004)

Parkin Regulates the Activity of Pyruvate Kinase M2
por: Liu, Kun, et al.
Publicado: (2016)

Clostridium difficile toxin B induces autophagic cell death in colonocytes
por: Chan, Hung, et al.
Publicado: (2018)

In vitro effect of uremic serum on barrier function and inflammation in human colonocytes
por: de Andrade, Laila Santos, et al.
Publicado: (2018)

Pyruvate Kinase M2 Expression, but Not Pyruvate Kinase Activity, Is Up-Regulated in a Grade-Specific Manner in Human Glioma
por: Mukherjee, Joydeep, et al.
Publicado: (2013)

Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis
por: Zhou, Haiping, et al.
Publicado: (2016)

The role of pyruvate kinase M2 in anticancer therapeutic treatments
por: Su, Qiongli, et al.
Publicado: (2019)

The effect of an interleukin receptor antagonist (IL-1ra) on colonocyte eicosanoid release
por: Smith, G. S., et al.
Publicado: (1996)

Proton pump inhibitor induced collagen expression in colonocytes is associated with collagenous colitis
por: Mori, Shiori, et al.
Publicado: (2017)

Excess Dietary Sugar Alters Colonocyte Metabolism and Impairs the Proliferative Response to Damage
por: Burr, Ansen H.P., et al.
Publicado: (2023)

Association of Phosphorylated Pyruvate Dehydrogenase with Pyruvate Kinase M2 Promotes PKM2 Stability in Response to Insulin
por: Hossain, Abu Jubayer, et al.
Publicado: (2023)

Agrimonia procera exerts antimicrobial effects, modulates the expression of defensins and cytokines in colonocytes and increases the immune response in lipopolysaccharide-challenged piglets
por: Gräber, Tobias, et al.
Publicado: (2018)

Pyruvate Kinase M2: A New Biomarker for the Early Detection of Diabetes-Induced Nephropathy
por: Park, Yeon Su, et al.
Publicado: (2023)

Pyruvate Kinase M2: A Potential Target for Regulating Inflammation
por: Alves-Filho, Jose C., et al.
Publicado: (2016)

Pyruvate kinase M2 regulates photoreceptor structure, function, and viability
por: Rajala, Ammaji, et al.
Publicado: (2018)

Posttranslational Modifications of Pyruvate Kinase M2: Tweaks that Benefit Cancer
por: Prakasam, Gopinath, et al.
Publicado: (2018)

An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor
por: Yuan, Meng, et al.
Publicado: (2018)

Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation
por: Mitchell, Alice Rose, et al.
Publicado: (2018)

The Multifarious Functions of Pyruvate Kinase M2 in Oral Cancer Cells
por: Kurihara-Shimomura, Miyako, et al.
Publicado: (2018)

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma
por: Davidson, Shawn M., et al.
Publicado: (2022)

Improved Recovery of Exfoliated Colonocytes from Feces Using Newly Developed Immunomagnetic Beads
por: Koga, Yoshikatsu, et al.
Publicado: (2008)

The Cause and Prevention of Anastomotic Recurrence following Colectomy: An Immunohistochemical Approach for Detecting Transforming Colonocytes
por: M., Arlen, et al.
Publicado: (2014)

TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer
por: Chapman, Christopher G., et al.
Publicado: (2015)

Effect of weight gain and weight loss on in vivo colonocyte proliferation rate in people with obesity
por: Magkos, Faidon, et al.
Publicado: (2017)

APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes
por: Parker, Taybor W., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2ajgor4ff9onenfvifbg4ahhiv