Multifunctional Anti-Alzheimer’s Disease Effects of Natural Xanthone Derivatives: A Primary Structure-Activity Evaluation

Background: A series of α-Mangostin (α-M) derivatives were designed and synthesized. α-M and four analogues were evaluated for their multifunctional anti-Alzheimer’s disease (anti-AD) effects on fibrillogenesis, microglial uptake, microglial degradation, and anti-neurotoxicity of Aβ, as well as LPS-...

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Detalles Bibliográficos
Autores principales: Hu, Xiaoyu, Liu, Chan, Wang, Kaichun, Zhao, Lanxue, Qiu, Yu, Chen, Hongzhuan, Hu, Jiangmiao, Xu, Jianrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130743/
https://www.ncbi.nlm.nih.gov/pubmed/35646819
http://dx.doi.org/10.3389/fchem.2022.842208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130743/
https://www.ncbi.nlm.nih.gov/pubmed/35646819
http://dx.doi.org/10.3389/fchem.2022.842208

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