Twist1 downregulation of PGC-1α decreases fatty acid oxidation in tubular epithelial cells, leading to kidney fibrosis

Rationale: A deficiency of fatty acid oxidation (FAO) is the metabolic hallmark in proximal tubular cells (PTCs) in renal fibrosis owing to utilization of fatty acids by PTCs as the main energy source. Lipid accumulation may promote lipotoxicity-induced pathological injury in renal tissue. However,...

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Detalles Bibliográficos
Autores principales: Liu, Limin, Ning, Xiaoxuan, Wei, Lei, Zhou, Ying, Zhao, Lijuan, Ma, Feng, Bai, Ming, Yang, Xiaoxia, Wang, Di, Sun, Shiren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131259/
https://www.ncbi.nlm.nih.gov/pubmed/35664054
http://dx.doi.org/10.7150/thno.71722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131259/
https://www.ncbi.nlm.nih.gov/pubmed/35664054
http://dx.doi.org/10.7150/thno.71722

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