Cargando…

Appraising diet–disease associations to be used in risk assessment, including an insight in nutritional epidemiology

High consumption of red meat, in particular of its processed products, has been linked to the development of various chronic diseases, and the need to reduce consumption levels of these products has been identified as a public health priority in Europe. Among the potential alternatives, pulses have...

Descripción completa

Detalles Bibliográficos
Autores principales: Mendes, Vânia, Niforou, Aikaterini, Naska, Androniki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131602/
https://www.ncbi.nlm.nih.gov/pubmed/35634559
http://dx.doi.org/10.2903/j.efsa.2022.e200411
_version_ 1784713207521214464
author Mendes, Vânia
Niforou, Aikaterini
Naska, Androniki
author_facet Mendes, Vânia
Niforou, Aikaterini
Naska, Androniki
author_sort Mendes, Vânia
collection PubMed
description High consumption of red meat, in particular of its processed products, has been linked to the development of various chronic diseases, and the need to reduce consumption levels of these products has been identified as a public health priority in Europe. Among the potential alternatives, pulses have gained a prominent position in recent years. Stemming from the broader context of the substitution of red meat in the diet with alternative plant‐based protein sources, this work programme was developed to address the need of improving the current understanding on the public health impact of potential substitutes. From a training perspective, the main goal was to advance the fellow’s background knowledge in the principles of nutritional epidemiology, while contributing to the harmonisation of food risk assessment practices across Europe. The activities developed comprised a comprehensive learning experience in the different components of the risk assessment framework, giving particular focus to the appraisal of epidemiological evidence within this context (hazard identification and characterisation). The fellow had the opportunity to gain hands‐on experience with EFSA’s databases among other relevant national and international data sources. The association between the consumption of legumes and risk of cardiovascular disease in particular was extensively explored and described by summarising the available evidence through dose–response meta‐analyses. The one‐stage approach method was used to explore the shape of the associations, including studies with as few as two levels of exposure, in a weighted mixed‐effects model. The analysis was also performed taking into account the potential risk of bias of included studies, assessed using the ROBINS‐I tool. Upon the completion of the activities carried out, the fellow made significant progress towards the learning outcomes expected to be achieved throughout the duration of the EU‐FORA fellowship period.
format Online
Article
Text
id pubmed-9131602
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-91316022022-05-26 Appraising diet–disease associations to be used in risk assessment, including an insight in nutritional epidemiology Mendes, Vânia Niforou, Aikaterini Naska, Androniki EFSA J Eu‐fora Series 4 High consumption of red meat, in particular of its processed products, has been linked to the development of various chronic diseases, and the need to reduce consumption levels of these products has been identified as a public health priority in Europe. Among the potential alternatives, pulses have gained a prominent position in recent years. Stemming from the broader context of the substitution of red meat in the diet with alternative plant‐based protein sources, this work programme was developed to address the need of improving the current understanding on the public health impact of potential substitutes. From a training perspective, the main goal was to advance the fellow’s background knowledge in the principles of nutritional epidemiology, while contributing to the harmonisation of food risk assessment practices across Europe. The activities developed comprised a comprehensive learning experience in the different components of the risk assessment framework, giving particular focus to the appraisal of epidemiological evidence within this context (hazard identification and characterisation). The fellow had the opportunity to gain hands‐on experience with EFSA’s databases among other relevant national and international data sources. The association between the consumption of legumes and risk of cardiovascular disease in particular was extensively explored and described by summarising the available evidence through dose–response meta‐analyses. The one‐stage approach method was used to explore the shape of the associations, including studies with as few as two levels of exposure, in a weighted mixed‐effects model. The analysis was also performed taking into account the potential risk of bias of included studies, assessed using the ROBINS‐I tool. Upon the completion of the activities carried out, the fellow made significant progress towards the learning outcomes expected to be achieved throughout the duration of the EU‐FORA fellowship period. John Wiley and Sons Inc. 2022-05-25 /pmc/articles/PMC9131602/ /pubmed/35634559 http://dx.doi.org/10.2903/j.efsa.2022.e200411 Text en © 2022 Wiley‐VCH Verlag GmbH & Co. KgaA on behalf of the European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Eu‐fora Series 4
Mendes, Vânia
Niforou, Aikaterini
Naska, Androniki
Appraising diet–disease associations to be used in risk assessment, including an insight in nutritional epidemiology
title Appraising diet–disease associations to be used in risk assessment, including an insight in nutritional epidemiology
title_full Appraising diet–disease associations to be used in risk assessment, including an insight in nutritional epidemiology
title_fullStr Appraising diet–disease associations to be used in risk assessment, including an insight in nutritional epidemiology
title_full_unstemmed Appraising diet–disease associations to be used in risk assessment, including an insight in nutritional epidemiology
title_short Appraising diet–disease associations to be used in risk assessment, including an insight in nutritional epidemiology
title_sort appraising diet–disease associations to be used in risk assessment, including an insight in nutritional epidemiology
topic Eu‐fora Series 4
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131602/
https://www.ncbi.nlm.nih.gov/pubmed/35634559
http://dx.doi.org/10.2903/j.efsa.2022.e200411
work_keys_str_mv AT mendesvania appraisingdietdiseaseassociationstobeusedinriskassessmentincludinganinsightinnutritionalepidemiology
AT niforouaikaterini appraisingdietdiseaseassociationstobeusedinriskassessmentincludinganinsightinnutritionalepidemiology
AT naskaandroniki appraisingdietdiseaseassociationstobeusedinriskassessmentincludinganinsightinnutritionalepidemiology