Estimating HLA haplotype frequencies from homozygous individuals – A Technical Report

We estimated HLA haplotype frequencies based on individuals homozygous for 4, 5 or 6 loci. Validation of our approach using a sample of over 3.4 million German individuals was successful. Compared to an expectation‐maximization algorithm, the errors were larger. However, our approach allows the uneq...

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Autores principales: Seitz, Susanne, Lange, Vinzenz, Norman, Paul J., Sauter, Jürgen, Schmidt, Alexander H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Population Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131737/
https://www.ncbi.nlm.nih.gov/pubmed/34570965
http://dx.doi.org/10.1111/iji.12553
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author Seitz, Susanne
Lange, Vinzenz
Norman, Paul J.
Sauter, Jürgen
Schmidt, Alexander H.
author_facet Seitz, Susanne
Lange, Vinzenz
Norman, Paul J.
Sauter, Jürgen
Schmidt, Alexander H.
author_sort Seitz, Susanne
collection PubMed
description We estimated HLA haplotype frequencies based on individuals homozygous for 4, 5 or 6 loci. Validation of our approach using a sample of over 3.4 million German individuals was successful. Compared to an expectation‐maximization algorithm, the errors were larger. However, our approach allows the unequivocal detection of rare haplotypes.
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spelling pubmed-91317372022-10-14 Estimating HLA haplotype frequencies from homozygous individuals – A Technical Report Seitz, Susanne Lange, Vinzenz Norman, Paul J. Sauter, Jürgen Schmidt, Alexander H. Int J Immunogenet Population Studies We estimated HLA haplotype frequencies based on individuals homozygous for 4, 5 or 6 loci. Validation of our approach using a sample of over 3.4 million German individuals was successful. Compared to an expectation‐maximization algorithm, the errors were larger. However, our approach allows the unequivocal detection of rare haplotypes. John Wiley and Sons Inc. 2021-09-27 2021-12 /pmc/articles/PMC9131737/ /pubmed/34570965 http://dx.doi.org/10.1111/iji.12553 Text en © 2021 The Authors. International Journal of Immunogenetics published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Population Studies
Seitz, Susanne
Lange, Vinzenz
Norman, Paul J.
Sauter, Jürgen
Schmidt, Alexander H.
Estimating HLA haplotype frequencies from homozygous individuals – A Technical Report
title Estimating HLA haplotype frequencies from homozygous individuals – A Technical Report
title_full Estimating HLA haplotype frequencies from homozygous individuals – A Technical Report
title_fullStr Estimating HLA haplotype frequencies from homozygous individuals – A Technical Report
title_full_unstemmed Estimating HLA haplotype frequencies from homozygous individuals – A Technical Report
title_short Estimating HLA haplotype frequencies from homozygous individuals – A Technical Report
title_sort estimating hla haplotype frequencies from homozygous individuals – a technical report
topic Population Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131737/
https://www.ncbi.nlm.nih.gov/pubmed/34570965
http://dx.doi.org/10.1111/iji.12553
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AT normanpaulj estimatinghlahaplotypefrequenciesfromhomozygousindividualsatechnicalreport
AT sauterjurgen estimatinghlahaplotypefrequenciesfromhomozygousindividualsatechnicalreport
AT schmidtalexanderh estimatinghlahaplotypefrequenciesfromhomozygousindividualsatechnicalreport

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