Anti-HK antibody reveals critical roles of a 20-residue HK region for Aβ-induced plasma contact system activation

Alzheimer’s disease (AD) is a neurodegenerative disorder and the leading cause of dementia. Vascular abnormalities and neuroinflammation play roles in AD pathogenesis. Plasma contact activation, which leads to fibrin clot formation and bradykinin release, is elevated in many AD patients, likely due...

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Detalles Bibliográficos
Autores principales: Chen, Zu-Lin, Singh, Pradeep Kumar, Horn, Katharina, Strickland, Sidney, Norris, Erin H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131899/
https://www.ncbi.nlm.nih.gov/pubmed/35147669
http://dx.doi.org/10.1182/bloodadvances.2021006612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131899/
https://www.ncbi.nlm.nih.gov/pubmed/35147669
http://dx.doi.org/10.1182/bloodadvances.2021006612

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