G6b-B regulates an essential step in megakaryocyte maturation

G6b-B is a megakaryocyte lineage-specific immunoreceptor tyrosine-based inhibition motif–containing receptor, essential for platelet homeostasis. Mice with a genomic deletion of the entire Mpig6b locus develop severe macrothrombocytopenia and myelofibrosis, which is reflected in humans with null mut...

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Detalles Bibliográficos
Autores principales: Becker, Isabelle C., Nagy, Zoltan, Manukjan, Georgi, Haffner-Luntzer, Melanie, Englert, Maximilian, Heib, Tobias, Vögtle, Timo, Gross, Carina, Bharti, Richa, Dietrich, Sascha, Mott, Kristina, Heck, Johannes, Stegmaier, Sebastian, Baranowsky, Anke, Schinke, Thorsten, Schlegel, Nicolas, Heckel, Tobias, Stegner, David, Pleines, Irina, Ignatius, Anita, Schulze, Harald, Nieswandt, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Stimulus Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131916/
https://www.ncbi.nlm.nih.gov/pubmed/35134123
http://dx.doi.org/10.1182/bloodadvances.2021006151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131916/
https://www.ncbi.nlm.nih.gov/pubmed/35134123
http://dx.doi.org/10.1182/bloodadvances.2021006151

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