K(+) efflux through postsynaptic NMDA receptors suppresses local astrocytic glutamate uptake

Glutamatergic transmission prompts K(+) efflux through postsynaptic NMDA receptors. The ensuing hotspot of extracellular K(+) elevation depolarizes presynaptic terminal, boosting glutamate release, but whether this also affects glutamate uptake in local astroglia has remained an intriguing question....

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Detalles Bibliográficos
Autores principales: Tyurikova, Olga, Shih, Pei‐Yu, Dembitskaya, Yulia, Savtchenko, Leonid P., McHugh, Thomas J., Rusakov, Dmitri A., Semyanov, Alexey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132042/
https://www.ncbi.nlm.nih.gov/pubmed/35084774
http://dx.doi.org/10.1002/glia.24150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132042/
https://www.ncbi.nlm.nih.gov/pubmed/35084774
http://dx.doi.org/10.1002/glia.24150

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