Identification of lung cancer drivers by comparison of the observed and the expected numbers of missense and nonsense mutations in individual human genes

Largely, cancer development is driven by acquisition and positive selection of somatic mutations that increase proliferation and survival of tumor cells. As a result, genes related to cancer development tend to have an excess of somatic mutations in them. An excess of missense and/or nonsense mutati...

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Detalles Bibliográficos
Autores principales: Gorlova, Olga Y., Kimmel, Marek, Tsavachidis, Spiridon, Amos, Christopher I., Gorlov, Ivan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132259/
https://www.ncbi.nlm.nih.gov/pubmed/35634240
http://dx.doi.org/10.18632/oncotarget.28231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132259/
https://www.ncbi.nlm.nih.gov/pubmed/35634240
http://dx.doi.org/10.18632/oncotarget.28231

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