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Identification of lung cancer drivers by comparison of the observed and the expected numbers of missense and nonsense mutations in individual human genes
Largely, cancer development is driven by acquisition and positive selection of somatic mutations that increase proliferation and survival of tumor cells. As a result, genes related to cancer development tend to have an excess of somatic mutations in them. An excess of missense and/or nonsense mutati...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132259/ https://www.ncbi.nlm.nih.gov/pubmed/35634240 http://dx.doi.org/10.18632/oncotarget.28231 |