Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis

[Image: see text] Hybrid compounds containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids were designed with the aid of docking and molecular mechanics studies. Following the synthesis of the compounds using a peptide-coupling methodology,...

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Detalles Bibliográficos
Autores principales: Martín-Cámara, Olmo, Arribas, Marina, Wells, Geoffrey, Morales-Tenorio, Marcos, Martín-Requero, Ángeles, Porras, Gracia, Martínez, Ana, Giorgi, Giorgio, López-Alvarado, Pilar, Lastres-Becker, Isabel, Menéndez, J. Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132363/
https://www.ncbi.nlm.nih.gov/pubmed/34985276
http://dx.doi.org/10.1021/acs.jmedchem.1c01255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132363/
https://www.ncbi.nlm.nih.gov/pubmed/34985276
http://dx.doi.org/10.1021/acs.jmedchem.1c01255

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