Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study

TANK-binding kinase 1 (TBK1), a noncanonical member of the inhibitor-kappaB kinases (IKKs) family, plays a vital role in coordinating the signalling pathways of innate immunity, involving in the process of neuroinflammation, autophagy, and oncogenesis. In current study, based on rational drug design...

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Detalles Bibliográficos
Autores principales: Sun, Yin, Tang, Haotian, Wang, Xiaoyan, Feng, Fang, Fan, Tiantian, Zhao, Dongmei, Xiong, Bing, Xie, Hua, Liu, Tongchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132415/
https://www.ncbi.nlm.nih.gov/pubmed/35587686
http://dx.doi.org/10.1080/14756366.2022.2076674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132415/
https://www.ncbi.nlm.nih.gov/pubmed/35587686
http://dx.doi.org/10.1080/14756366.2022.2076674

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