Cargando…

Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study

TANK-binding kinase 1 (TBK1), a noncanonical member of the inhibitor-kappaB kinases (IKKs) family, plays a vital role in coordinating the signalling pathways of innate immunity, involving in the process of neuroinflammation, autophagy, and oncogenesis. In current study, based on rational drug design...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Yin, Tang, Haotian, Wang, Xiaoyan, Feng, Fang, Fan, Tiantian, Zhao, Dongmei, Xiong, Bing, Xie, Hua, Liu, Tongchao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132415/ https://www.ncbi.nlm.nih.gov/pubmed/35587686 http://dx.doi.org/10.1080/14756366.2022.2076674

Ejemplares similares

1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications
por: Donaire-Arias, Ana, et al.
Publicado: (2022)

Synthesis and vectorial functionalisation of pyrazolo[3,4-c]pyridines
por: Bedwell, Elizabeth V., et al.
Publicado: (2023)

3-Iodo-1H-pyrazolo[3,4-b]pyridine
por: Huang, Ping-Hsin, et al.
Publicado: (2014)

Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as potent ALK-L1196M inhibitors
por: Nam, Yunju, et al.
Publicado: (2019)

Potent Alkaline Phosphatase Inhibitors, Pyrazolo-Oxothiazolidines: Synthesis, Biological Evaluation, Molecular Docking, and Kinetic Studies
por: Hosseini Nasab, Narges, et al.
Publicado: (2022)

3,4,6-Trimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine
por: Hamri, Salha, et al.
Publicado: (2010)

Structural Basis for PPARα Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives
por: Yoshida, Takuya, et al.
Publicado: (2020)

Pyridine-2-carboxylic acid as an effectual catalyst for rapid multi-component synthesis of pyrazolo[3,4-b]quinolinones
por: Sharma, Mayank G., et al.
Publicado: (2020)

Catalytic synthesis of new pyrazolo [3,4-b] pyridine via a cooperative vinylogous anomeric-based oxidation
por: Sepehrmansourie, Hassan, et al.
Publicado: (2022)

Synthesis of 3,6-diaryl-1H-pyrazolo[3,4-b]pyridines via one-pot sequential Suzuki–Miyaura coupling
por: Urvashi,, et al.
Publicado: (2018)

Four-Component Bicyclization Approaches to Skeletally Diverse Pyrazolo[3,4-b]pyridine Derivatives
por: Tu, Xing-Jun, et al.
Publicado: (2014)

Screening of Heteroaromatic Scaffolds against Cystathionine Beta-Synthase Enables Identification of Substituted Pyrazolo[3,4-c]Pyridines as Potent and Selective Orthosteric Inhibitors
por: Fantel, Anna-Maria, et al.
Publicado: (2020)

New approach toward the synthesis of deuterated pyrazolo[1,5-a]pyridines and 1,2,4-triazolo[1,5-a]pyridines
por: Vorob’ev, Aleksey Yu, et al.
Publicado: (2017)

Pyrazolo[4,3-c]pyridine Sulfonamides as Carbonic Anhydrase Inhibitors: Synthesis, Biological and In Silico Studies
por: Angeli, Andrea, et al.
Publicado: (2022)

Organometallic 3-(1H-Benzimidazol-2-yl)-1H-pyrazolo[3,4-b]pyridines as Potential Anticancer Agents
por: Stepanenko, Iryna N., et al.
Publicado: (2011)

5-(Pyridin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
por: Alsubari, Abdulsalam, et al.
Publicado: (2011)

Straightforward and Efficient Protocol for the Synthesis of Pyrazolo [4,3-b]pyridines and Indazoles
por: Nikol’skiy, Vladislav V., et al.
Publicado: (2023)

Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors
por: Wu, Xiaowei, et al.
Publicado: (2021)

Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4-g]isoquinolines
por: Defois, Mathilde, et al.
Publicado: (2022)

5,6-Dimethyl-4-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-amine
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2012)

Modular Synthesis and Antiproliferative Activity of New Dihydro-1H-pyrazolo[1,3-b]pyridine Embelin Derivatives
por: Martín-Acosta, Pedro, et al.
Publicado: (2021)

Synthesis of Fluorescent 1,7-Dipyridyl-bis-pyrazolo[3,4-b:4′,3′-e]pyridines: Design of Reversible Chemosensors for Nanomolar Detection of Cu(2+)
por: García, Mauricio, et al.
Publicado: (2019)

Synthesis of some new pyrazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine, 1,3,4-thiadiazole and pyridine derivatives containing 1,2,3-triazole moiety
por: Abdelriheem, Nadia A., et al.
Publicado: (2017)

Alcohol Participates in the Synthesis of Functionalized Coumarin-Fused Pyrazolo[3,4-b]Pyridine from a One-Pot Three-Component Reaction
por: Lin, Wei, et al.
Publicado: (2019)

Crystal structure of 3-methyl-1-phenyl-6-propylamino-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile
por: Jasinski, Jerry P., et al.
Publicado: (2015)

Three New Supramolecular Coordination Polymers Based on 1H-pyrazolo[3,4-b]pyridin-3-amine and 1,3-benzenedicarboxylate Derivatives
por: Xu, Yun, et al.
Publicado: (2019)

4-Hydrazino-1-methylpyrazolo[3,4-d]pyrimidine
por: Dolzhenko, Anton V., et al.
Publicado: (2009)

1H-Pyrazolo[3,4-b]quinolines: Synthesis and Properties over 100 Years of Research
por: Danel, Andrzej, et al.
Publicado: (2022)

6-Amino-3-methyl-4-(4-nitrophenyl)-1-phenylpyrazolo[3,4-b]pyridine-5-carbonitrile
por: Zhang, Xin-Ying, et al.
Publicado: (2008)

Polyethylene Glycol (PEG-400): An Efficient and Recyclable Reaction Medium for the Synthesis of Pyrazolo[3,4-b]pyridin-6(7H)-one Derivatives
por: Zhong, Xiaoxing, et al.
Publicado: (2013)

Discovery of New 1,4,6-Trisubstituted-1H-pyrazolo[3,4-b]pyridines with Anti-Tumor Efficacy in Mouse Model of Breast Cancer †
por: Georgiou, Maria, et al.
Publicado: (2023)

Discovery of pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and molecular modeling investigations
por: Nassar, Ibrahim F., et al.
Publicado: (2022)

Biological Evaluation and Molecular Docking with In Silico Physicochemical, Pharmacokinetic and Toxicity Prediction of Pyrazolo[1,5-a]pyrimidines
por: Naglah, Ahmed M., et al.
Publicado: (2020)

Synthesis and anti-HSV-1 evaluation of new 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridines and 3H-pyrido[2,3-b]pyrazolo[3,4-h]-1,6-naphthyridines
por: Bernardino, Alice MR, et al.
Publicado: (2012)

Synthesis and Antimicrobial Evaluation of Some Novel Bis-α,β-Unsaturated Ketones, Nicotinonitrile, 1,2-Dihydropyridine-3-carbonitrile, Fused Thieno[2,3-b]pyridine and Pyrazolo[3,4-b]pyridine Derivatives
por: Altalbawy, Farag M. A.
Publicado: (2013)

4-Benzylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine
por: El Fal, Mohammed, et al.
Publicado: (2013)

Synthesis of Diversified Pyrazolo[3,4-b]pyridine Frameworks from 5-Aminopyrazoles and Alkynyl Aldehydes via Switchable C≡C Bond Activation Approaches
por: Miao, Xiao-Yu, et al.
Publicado: (2022)

Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives
por: Kandeel, Manal M., et al.
Publicado: (2012)

Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors
por: Greco, Chiara, et al.
Publicado: (2020)

Oxidative [3+2]Cycloaddition of Alkynylphosphonates with Heterocyclic N-Imines: Synthesis of Pyrazolo[1,5-a]Pyridine-3-phosphonates
por: Philippov, Igor, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lfp9cnu0kdk5tiugh2bmjmjav5