Deep mutational engineering of broadly-neutralizing nanobodies accommodating SARS-CoV-1 and 2 antigenic drift

Here, we report the molecular engineering of nanobodies that bind with picomolar affinity to both SARS-CoV-1 and SARS-CoV-2 receptor-binding domains (RBD) and are highly neutralizing. We applied deep mutational engineering to VHH72, a nanobody initially specific for SARS-CoV-1 RBD with little cross-...

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Detalles Bibliográficos
Autores principales: Laroche, Adrien, Orsini Delgado, Maria Lucia, Chalopin, Benjamin, Cuniasse, Philippe, Dubois, Steven, Sierocki, Raphaël, Gallais, Fabrice, Debroas, Stéphanie, Bellanger, Laurent, Simon, Stéphanie, Maillère, Bernard, Nozach, Hervé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132424/
https://www.ncbi.nlm.nih.gov/pubmed/35593235
http://dx.doi.org/10.1080/19420862.2022.2076775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132424/
https://www.ncbi.nlm.nih.gov/pubmed/35593235
http://dx.doi.org/10.1080/19420862.2022.2076775

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