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Differential metabolic requirement governed by transcription factor c-Maf dictates innate γδT17 effector functionality in mice and humans
Cellular metabolism has been proposed to govern distinct γδ T cell effector functions, but the underlying molecular mechanisms remain unclear. We show that interleukin-17 (IL-17)–producing γδ T (γδT17) and interferon-γ (IFN-γ)–producing γδ T (γδT1) cells have differential metabolic requirements and...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132442/ https://www.ncbi.nlm.nih.gov/pubmed/35613277 http://dx.doi.org/10.1126/sciadv.abm9120 |