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Differential metabolic requirement governed by transcription factor c-Maf dictates innate γδT17 effector functionality in mice and humans

Cellular metabolism has been proposed to govern distinct γδ T cell effector functions, but the underlying molecular mechanisms remain unclear. We show that interleukin-17 (IL-17)–producing γδ T (γδT17) and interferon-γ (IFN-γ)–producing γδ T (γδT1) cells have differential metabolic requirements and...

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Detalles Bibliográficos
Autores principales:	Chen, Xu, Cai, Yihua, Hu, Xiaoling, Ding, Chuanlin, He, Liqing, Zhang, Xiang, Chen, Fuxiang, Yan, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132442/ https://www.ncbi.nlm.nih.gov/pubmed/35613277 http://dx.doi.org/10.1126/sciadv.abm9120

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