mTOR deletion ameliorates CD4 + T cell apoptosis during sepsis by improving autophagosome-lysosome fusion

Autophagy dysfunction contributes to CD4 + T cell apoptosis during sepsis leading to impairment of adaptive immunity. However, the underlying mechanism is unclear. The mammalian target of rapamycin (mTOR) pathway modulates CD4 + T cell survival during sepsis through mechanisms that are not fully und...

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Detalles Bibliográficos
Autores principales: Wang, Hao, Bai, Guangxu, Chen, Jianwei, Han, Wen, Guo, Ran, Cui, Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132821/
https://www.ncbi.nlm.nih.gov/pubmed/35435531
http://dx.doi.org/10.1007/s10495-022-01719-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132821/
https://www.ncbi.nlm.nih.gov/pubmed/35435531
http://dx.doi.org/10.1007/s10495-022-01719-y

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