Mutational signatures are markers of drug sensitivity of cancer cells

Genomic analyses have revealed mutational footprints associated with DNA maintenance gone awry, or with mutagen exposures. Because cancer therapeutics often target DNA synthesis or repair, we asked if mutational signatures make useful markers of drug sensitivity. We detect mutational signatures in c...

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Detalles Bibliográficos
Autores principales: Levatić, Jurica, Salvadores, Marina, Fuster-Tormo, Francisco, Supek, Fran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132939/
https://www.ncbi.nlm.nih.gov/pubmed/35614096
http://dx.doi.org/10.1038/s41467-022-30582-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132939/
https://www.ncbi.nlm.nih.gov/pubmed/35614096
http://dx.doi.org/10.1038/s41467-022-30582-3

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