Cargando…

Mutational signatures are markers of drug sensitivity of cancer cells

Genomic analyses have revealed mutational footprints associated with DNA maintenance gone awry, or with mutagen exposures. Because cancer therapeutics often target DNA synthesis or repair, we asked if mutational signatures make useful markers of drug sensitivity. We detect mutational signatures in c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Levatić, Jurica, Salvadores, Marina, Fuster-Tormo, Francisco, Supek, Fran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132939/ https://www.ncbi.nlm.nih.gov/pubmed/35614096 http://dx.doi.org/10.1038/s41467-022-30582-3

Ejemplares similares

A framework for mutational signature analysis based on DNA shape parameters
por: Karolak, Aleksandra, et al.
Publicado: (2022)

Matching cell lines with cancer type and subtype of origin via mutational, epigenomic, and transcriptomic patterns
por: Salvadores, Marina, et al.
Publicado: (2020)

Passenger mutations accurately classify human tumors
por: Salvadores, Marina, et al.
Publicado: (2019)

Prevalence, causes and impact of TP53-loss phenocopying events in human tumors
por: Fito-Lopez, Bruno, et al.
Publicado: (2023)

Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells
por: Biayna, Josep, et al.
Publicado: (2021)

Differential DNA mismatch repair underlies mutation rate variation across the human genome
por: Supek, Fran, et al.
Publicado: (2015)

Nucleoid-Associated Proteins Affect Mutation Dynamics in E. coli in a Growth Phase-Specific Manner
por: Warnecke, Tobias, et al.
Publicado: (2012)

Inferring gene function from evolutionary change in signatures of translation efficiency
por: Krisko, Anita, et al.
Publicado: (2014)

Proteome sequence features carry signatures of the environmental niche of prokaryotes
por: Smole, Zlatko, et al.
Publicado: (2011)

Proton and alpha radiation-induced mutational profiles in human cells
por: Delhomme, Tiffany M., et al.
Publicado: (2023)

Phyletic Profiling with Cliques of Orthologs Is Enhanced by Signatures of Paralogy Relationships
por: Škunca, Nives, et al.
Publicado: (2013)

DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers
por: Mas-Ponte, David, et al.
Publicado: (2020)

MUFFINN: cancer gene discovery via network analysis of somatic mutation data
por: Cho, Ara, et al.
Publicado: (2016)

Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits
por: Park, Solip, et al.
Publicado: (2018)

Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers
por: Park, Solip, et al.
Publicado: (2021)

Comparison of codon usage measures and their applicability in prediction of microbial gene expressivity
por: Supek, Fran, et al.
Publicado: (2005)

Correction: Comparison of codon usage measures and their applicability in prediction of microbial gene expressivity
por: Supek, Fran, et al.
Publicado: (2010)

The rules and impact of nonsense-mediated mRNA decay in human cancers
por: Lindeboom, Rik G.H., et al.
Publicado: (2016)

The impact of rare germline variants on human somatic mutation processes
por: Vali-Pour, Mischan, et al.
Publicado: (2022)

Signatures of Drug Sensitivity in Nonsmall Cell Lung Cancer
por: Gong, Hua C., et al.
Publicado: (2011)

Spectrum of DNA mismatch repair failures viewed through the lens of cancer genomics and implications for therapy
por: Mas-Ponte, David, et al.
Publicado: (2022)

Patterns of diverse gene functions in genomic neighborhoods predict gene function and phenotype
por: Mihelčić, Matej, et al.
Publicado: (2019)

Author Correction: The impact of rare germline variants on human somatic mutation processes
por: Vali-Pour, Mischan, et al.
Publicado: (2023)

The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy
por: Lindeboom, Rik G.H., et al.
Publicado: (2019)

TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening
por: Álvarez, Miguel M., et al.
Publicado: (2022)

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms
por: Supek, Fran, et al.
Publicado: (2011)

Hydroxymethylated Cytosines Are Associated with Elevated C to G Transversion Rates
por: Supek, Fran, et al.
Publicado: (2014)

Global Shifts in Genome and Proteome Composition Are Very Tightly Coupled
por: Brbić, Maria, et al.
Publicado: (2015)

Systematic identification of genomic markers of drug sensitivity in cancer cells
por: Garnett, Mathew J., et al.
Publicado: (2012)

The evolutionary signal in metagenome phyletic profiles predicts many gene functions
por: Vidulin, Vedrana, et al.
Publicado: (2018)

Translational Selection Is Ubiquitous in Prokaryotes
por: Supek, Fran, et al.
Publicado: (2010)

Combining Mutational Signatures, Clonal Fitness, and Drug Affinity to Define Drug-Specific Resistance Mutations in Cancer
por: Kaserer, Teresa, et al.
Publicado: (2018)

Replication Study: Systematic identification of genomic markers of drug sensitivity in cancer cells
por: Vanden Heuvel, John P, et al.
Publicado: (2018)

Registered report: Systematic identification of genomic markers of drug sensitivity in cancer cells
por: Vanden Heuvel, John P, et al.
Publicado: (2016)

Interactive webtool for analyzing drug sensitivity and resistance associated with genetic signatures of cancer cell lines
por: Boeschen, Myriam, et al.
Publicado: (2022)

The landscape of microbial phenotypic traits and associated genes
por: Brbić, Maria, et al.
Publicado: (2016)

Elevated Rate of Genome Rearrangements in Radiation-Resistant Bacteria
por: Repar, Jelena, et al.
Publicado: (2017)

Signatures of mutational processes in human cancer
por: Alexandrov, Ludmil B., et al.
Publicado: (2013)

Mutation Signatures Including APOBEC in Cancer Cell Lines
por: Jarvis, Matthew C, et al.
Publicado: (2018)

A mutation in exon 7 of the human cytochrome P-4501A1 gene as marker for sensitivity to anti-cancer drugs?
por: Peters, W. H., et al.
Publicado: (1997)

Cannot write session to /tmp/vufind_sessions/sess_5j1gjnf79nvaf5amt3gd5m328d