Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity

In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect chemicals present in the environment, and to adapt to various levels of stimulation. The contribution of endogenous and external factors to these neuronal identities remains to be determined. Taking advantage of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Horgue, Luis Flores, Assens, Alexis, Fodoulian, Leon, Marconi, Leonardo, Tuberosa, Joël, Haider, Alexander, Boillat, Madlaina, Carleton, Alan, Rodriguez, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132991/
https://www.ncbi.nlm.nih.gov/pubmed/35614043
http://dx.doi.org/10.1038/s41467-022-30511-4
_version_ 1784713499544387584
author Horgue, Luis Flores
Assens, Alexis
Fodoulian, Leon
Marconi, Leonardo
Tuberosa, Joël
Haider, Alexander
Boillat, Madlaina
Carleton, Alan
Rodriguez, Ivan
author_facet Horgue, Luis Flores
Assens, Alexis
Fodoulian, Leon
Marconi, Leonardo
Tuberosa, Joël
Haider, Alexander
Boillat, Madlaina
Carleton, Alan
Rodriguez, Ivan
author_sort Horgue, Luis Flores
collection PubMed
description In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect chemicals present in the environment, and to adapt to various levels of stimulation. The contribution of endogenous and external factors to these neuronal identities remains to be determined. Taking advantage of the parallel coding lines present in the olfactory system, we explored the potential variations of neuronal identities before and after olfactory experience. We found that at rest, the transcriptomic profiles of mouse olfactory sensory neuron populations are already divergent, specific to the olfactory receptor they express, and are associated with the sequence of these latter. These divergent profiles further evolve in response to the environment, as odorant exposure leads to reprogramming via the modulation of transcription. These findings highlight a broad range of sensory neuron identities that are present at rest and that adapt to the experience of the individual, thus adding to the complexity and flexibility of sensory coding.
format Online
Article
Text
id pubmed-9132991
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-91329912022-05-27 Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity Horgue, Luis Flores Assens, Alexis Fodoulian, Leon Marconi, Leonardo Tuberosa, Joël Haider, Alexander Boillat, Madlaina Carleton, Alan Rodriguez, Ivan Nat Commun Article In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect chemicals present in the environment, and to adapt to various levels of stimulation. The contribution of endogenous and external factors to these neuronal identities remains to be determined. Taking advantage of the parallel coding lines present in the olfactory system, we explored the potential variations of neuronal identities before and after olfactory experience. We found that at rest, the transcriptomic profiles of mouse olfactory sensory neuron populations are already divergent, specific to the olfactory receptor they express, and are associated with the sequence of these latter. These divergent profiles further evolve in response to the environment, as odorant exposure leads to reprogramming via the modulation of transcription. These findings highlight a broad range of sensory neuron identities that are present at rest and that adapt to the experience of the individual, thus adding to the complexity and flexibility of sensory coding. Nature Publishing Group UK 2022-05-25 /pmc/articles/PMC9132991/ /pubmed/35614043 http://dx.doi.org/10.1038/s41467-022-30511-4 Text en © The Author(s) 2022, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Horgue, Luis Flores
Assens, Alexis
Fodoulian, Leon
Marconi, Leonardo
Tuberosa, Joël
Haider, Alexander
Boillat, Madlaina
Carleton, Alan
Rodriguez, Ivan
Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity
title Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity
title_full Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity
title_fullStr Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity
title_full_unstemmed Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity
title_short Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity
title_sort transcriptional adaptation of olfactory sensory neurons to gpcr identity and activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132991/
https://www.ncbi.nlm.nih.gov/pubmed/35614043
http://dx.doi.org/10.1038/s41467-022-30511-4
work_keys_str_mv AT horgueluisflores transcriptionaladaptationofolfactorysensoryneuronstogpcridentityandactivity
AT assensalexis transcriptionaladaptationofolfactorysensoryneuronstogpcridentityandactivity
AT fodoulianleon transcriptionaladaptationofolfactorysensoryneuronstogpcridentityandactivity
AT marconileonardo transcriptionaladaptationofolfactorysensoryneuronstogpcridentityandactivity
AT tuberosajoel transcriptionaladaptationofolfactorysensoryneuronstogpcridentityandactivity
AT haideralexander transcriptionaladaptationofolfactorysensoryneuronstogpcridentityandactivity
AT boillatmadlaina transcriptionaladaptationofolfactorysensoryneuronstogpcridentityandactivity
AT carletonalan transcriptionaladaptationofolfactorysensoryneuronstogpcridentityandactivity
AT rodriguezivan transcriptionaladaptationofolfactorysensoryneuronstogpcridentityandactivity