Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity
In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect chemicals present in the environment, and to adapt to various levels of stimulation. The contribution of endogenous and external factors to these neuronal identities remains to be determined. Taking advantage of t...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132991/ https://www.ncbi.nlm.nih.gov/pubmed/35614043 http://dx.doi.org/10.1038/s41467-022-30511-4 |
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author | Horgue, Luis Flores Assens, Alexis Fodoulian, Leon Marconi, Leonardo Tuberosa, Joël Haider, Alexander Boillat, Madlaina Carleton, Alan Rodriguez, Ivan |
author_facet | Horgue, Luis Flores Assens, Alexis Fodoulian, Leon Marconi, Leonardo Tuberosa, Joël Haider, Alexander Boillat, Madlaina Carleton, Alan Rodriguez, Ivan |
author_sort | Horgue, Luis Flores |
collection | PubMed |
description | In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect chemicals present in the environment, and to adapt to various levels of stimulation. The contribution of endogenous and external factors to these neuronal identities remains to be determined. Taking advantage of the parallel coding lines present in the olfactory system, we explored the potential variations of neuronal identities before and after olfactory experience. We found that at rest, the transcriptomic profiles of mouse olfactory sensory neuron populations are already divergent, specific to the olfactory receptor they express, and are associated with the sequence of these latter. These divergent profiles further evolve in response to the environment, as odorant exposure leads to reprogramming via the modulation of transcription. These findings highlight a broad range of sensory neuron identities that are present at rest and that adapt to the experience of the individual, thus adding to the complexity and flexibility of sensory coding. |
format | Online Article Text |
id | pubmed-9132991 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-91329912022-05-27 Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity Horgue, Luis Flores Assens, Alexis Fodoulian, Leon Marconi, Leonardo Tuberosa, Joël Haider, Alexander Boillat, Madlaina Carleton, Alan Rodriguez, Ivan Nat Commun Article In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect chemicals present in the environment, and to adapt to various levels of stimulation. The contribution of endogenous and external factors to these neuronal identities remains to be determined. Taking advantage of the parallel coding lines present in the olfactory system, we explored the potential variations of neuronal identities before and after olfactory experience. We found that at rest, the transcriptomic profiles of mouse olfactory sensory neuron populations are already divergent, specific to the olfactory receptor they express, and are associated with the sequence of these latter. These divergent profiles further evolve in response to the environment, as odorant exposure leads to reprogramming via the modulation of transcription. These findings highlight a broad range of sensory neuron identities that are present at rest and that adapt to the experience of the individual, thus adding to the complexity and flexibility of sensory coding. Nature Publishing Group UK 2022-05-25 /pmc/articles/PMC9132991/ /pubmed/35614043 http://dx.doi.org/10.1038/s41467-022-30511-4 Text en © The Author(s) 2022, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Horgue, Luis Flores Assens, Alexis Fodoulian, Leon Marconi, Leonardo Tuberosa, Joël Haider, Alexander Boillat, Madlaina Carleton, Alan Rodriguez, Ivan Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity |
title | Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity |
title_full | Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity |
title_fullStr | Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity |
title_full_unstemmed | Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity |
title_short | Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity |
title_sort | transcriptional adaptation of olfactory sensory neurons to gpcr identity and activity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132991/ https://www.ncbi.nlm.nih.gov/pubmed/35614043 http://dx.doi.org/10.1038/s41467-022-30511-4 |
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