Cargando…

Dysfunction of the energy sensor NFE2L1 triggers uncontrollable AMPK signaling and glucose metabolism reprogramming

The antioxidant transcription factor NFE2L1 (also called Nrf1) acts as a core regulator of redox signaling and metabolism homeostasis, and thus, its dysfunction results in multiple systemic metabolic diseases. However, the molecular mechanism(s) by which NFE2L1 regulates glycose and lipid metabolism...

Descripción completa

Detalles Bibliográficos
Autores principales: Qiu, Lu, Yang, Qiufang, Zhao, Wenshan, Xing, Yadi, Li, Peng, Zhou, Xiaowen, Ning, Haoming, Shi, Ranran, Gou, Shanshan, Chen, Yalan, Zhai, Wenjie, Wu, Yahong, Li, Guodong, Chen, Zhenzhen, Ren, Yonggang, Gao, Yanfeng, Zhang, Yiguo, Qi, Yuanming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133051/
https://www.ncbi.nlm.nih.gov/pubmed/35614059
http://dx.doi.org/10.1038/s41419-022-04917-3