Evolutionary association of receptor-wide amino acids with G protein–coupling selectivity in aminergic GPCRs

G protein-coupled receptors (GPCRs) induce signal transduction pathways through coupling to four main subtypes of G proteins (G(s), G(i), G(q), and G(12/13)), selectively. However, G protein selective activation mechanisms and residual determinants in GPCRs have remained obscure. Herein, we performe...

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Detalles Bibliográficos
Autores principales: Selçuk, Berkay, Erol, Ismail, Durdağı, Serdar, Adebali, Ogün
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133432/
https://www.ncbi.nlm.nih.gov/pubmed/35613896
http://dx.doi.org/10.26508/lsa.202201439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133432/
https://www.ncbi.nlm.nih.gov/pubmed/35613896
http://dx.doi.org/10.26508/lsa.202201439

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