Aβ oligomer concentration in mouse and human brain and its drug-induced reduction ex vivo

The elimination of amyloid beta (Aβ) oligomers is a promising strategy for therapeutic drug development of Alzheimer’s disease (AD). AD mouse models that develop Aβ pathology have been used to demonstrate in vivo efficacy of compounds that later failed in clinical development. Here, we analyze the c...

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Detalles Bibliográficos
Autores principales: Kass, Bettina, Schemmert, Sarah, Zafiu, Christian, Pils, Marlene, Bannach, Oliver, Kutzsche, Janine, Bujnicki, Tuyen, Willbold, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133466/
https://www.ncbi.nlm.nih.gov/pubmed/35584626
http://dx.doi.org/10.1016/j.xcrm.2022.100630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133466/
https://www.ncbi.nlm.nih.gov/pubmed/35584626
http://dx.doi.org/10.1016/j.xcrm.2022.100630

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