Cargando…

Development of Novel CD47-Specific ADCs Possessing High Potency Against Non-Small Cell Lung Cancer in vitro and in vivo

Targeted therapies hold promise for efficiently and accurately delivering cytotoxic drugs directly to tumor tissue to exert anticancer effects. CD47 is a membrane protein expressed in a variety of malignant tumors and hematopoietic cells, which plays a key role in immune escape and tumor progression...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chiang, Zu-Chian, Fang, Shubin, Shen, Yang-kun, Cui, Dongya, Weng, Huanjiao, Wang, Dawei, Zhao, Yuxiang, Lin, Jizhen, Chen, Qi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133542/ https://www.ncbi.nlm.nih.gov/pubmed/35646646 http://dx.doi.org/10.3389/fonc.2022.857927

Ejemplares similares

Ex vivo near-infrared targeted imaging of human bladder carcinoma by ICG-anti-CD47
por: Hao, Haifeng, et al.
Publicado: (2023)

Targeting CD47 as a Novel Immunotherapy for Breast Cancer
por: Chen, Can, et al.
Publicado: (2022)

Therapeutic Targeting of the Macrophage Immune Checkpoint CD47 in Myeloid Malignancies
por: Chao, Mark P., et al.
Publicado: (2020)

A Novel Blockade CD47 Antibody With Therapeutic Potential for Cancer
por: Lin, Fangzhen, et al.
Publicado: (2021)

Ex Vivo Near-Infrared Molecular Imaging of Human Upper Urinary Tract Urothelial Carcinoma With a CD47-Based Targeted Tracer
por: Yan, Pengyu, et al.
Publicado: (2022)

Correlation between ADC, ADC ratio, and Gleason Grade group in prostate cancer patients undergoing radical prostatectomy: Retrospective multicenter study with different MRI scanners
por: Bengtsson, Johan, et al.
Publicado: (2023)

In Situ Tumor Vaccine Expressing Anti-CD47 Antibody Enhances Antitumor Immunity
por: Zhang, Bin, et al.
Publicado: (2022)

Contribution of Diffusion-Weighted Imaging and ADC Values to Papillary Breast Lesions
por: Lv, Wenjie, et al.
Publicado: (2022)

The Differential Expression of CD47 may be Related to the Pathogenesis From Myelodysplastic Syndromes to Acute Myeloid Leukemia
por: Yan, Xiao, et al.
Publicado: (2022)

Identification of Schlafen-11 as a Target of CD47 Signaling That Regulates Sensitivity to Ionizing Radiation and Topoisomerase Inhibitors
por: Kaur, Sukhbir, et al.
Publicado: (2019)

Increased tumour ADC value during chemotherapy predicts improved survival in unresectable pancreatic cancer
por: Nishiofuku, Hideyuki, et al.
Publicado: (2015)

Oesophageal squamous cell carcinoma: histogram-derived ADC parameters are not predictive of tumour response to chemoradiotherapy
por: Kozumi, Maiko, et al.
Publicado: (2018)

Differentiation of Breast Lesions and Distinguishing Their Histological Subtypes Using Diffusion-Weighted Imaging and ADC Values
por: Maric, Jelena, et al.
Publicado: (2020)

Antibody-Drug Conjugates (ADC) Against Cancer Stem-Like Cells (CSC)—Is There Still Room for Optimism?
por: Marcucci, Fabrizio, et al.
Publicado: (2019)

A Novel Affinity Engineered Anti-CD47 Antibody With Improved Therapeutic Index That Preserves Erythrocytes and Normal Immune Cells
por: Thaker, Youg R., et al.
Publicado: (2022)

CD47 expression is critical for CAR T-cell survival in vivo
por: Beckett, Alex N, et al.
Publicado: (2023)

Coumarin-Annulated Ferrocenyl 1,3-Oxazine Derivatives Possessing In Vitro Antimalarial and Antitrypanosomal Potency
por: Mbaba, Mziyanda, et al.
Publicado: (2021)

Broad reactivity and enhanced potency of recombinant anti-EGFR × anti-CD3 bispecific antibody-armed activated T cells against solid tumours
por: Huang, Manley T. F., et al.
Publicado: (2022)

Cuproptosis-related gene expression is associated with immune infiltration and CD47/CD24 expression in glioblastoma, and a risk score based on these genes can predict the survival and prognosis of patients
por: Li, Erliang, et al.
Publicado: (2023)

Establishing ADC-Based Histogram and Texture Features for Early Treatment-Induced Changes in Head and Neck Squamous Cell Carcinoma
por: Rodrigues, Anna, et al.
Publicado: (2021)

Tumor cellularity beyond the visible in soft tissue sarcomas: Results of an ADC-based, single center, and preliminary radiomics study
por: Giraudo, Chiara, et al.
Publicado: (2022)

Value of ADC measurements for nodal staging after chemoradiation in locally advanced rectal cancer—a per lesion validation study
por: Lambregts, Doenja M. J., et al.
Publicado: (2010)

ErbB2 Targeted Epigenetic Modulation: Anti-tumor Efficacy of the ADC Trastuzumab-HDACi ST8176AA1
por: Milazzo, Ferdinando Maria, et al.
Publicado: (2020)

Pretreatment ADC is not a prognostic factor for local recurrences in head and neck squamous cell carcinoma when clinical T-stage is known
por: Peltenburg, Boris, et al.
Publicado: (2019)

Thrombospondin-1 Receptor CD47 Overexpression Contributes to P-Glycoprotein-Mediated Multidrug Resistance Against Doxorubicin in Thyroid Carcinoma FTC-133 Cells
por: Courageot, Marie-Pierre, et al.
Publicado: (2020)

Membrane fusogenic lysine type lipid assemblies possess enhanced NLRP3 inflammasome activation potency
por: He, Jieyan, et al.
Publicado: (2019)

Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo
por: Reed, Michelle, et al.
Publicado: (2019)

Mechanisms of ADC Toxicity and Strategies to Increase ADC Tolerability
por: Nguyen, Toan D., et al.
Publicado: (2023)

Development of COTS ADC SEE Test System for the ATLAS LAr Calorimeter Upgrade
por: Hu, Xueye, et al.
Publicado: (2014)

Response Prediction to Concurrent Chemoradiotherapy in Esophageal Squamous Cell Carcinoma Using Delta-Radiomics Based on Sequential Whole-Tumor ADC Map
por: An, Dianzheng, et al.
Publicado: (2022)

A Potent and Selective Dual Inhibitor of AXL and MERTK Possesses Both Immunomodulatory and Tumor-Targeted Activity
por: Rios-Doria, Jonathan, et al.
Publicado: (2020)

SFPQ Promotes Lung Cancer Malignancy via Regulation of CD44 v6 Expression
por: Yang, Libang, et al.
Publicado: (2022)

Those ADCs
Publicado: (1971)

Dynamic Three-Dimensional ADC Changes of Parotid Glands During Radiotherapy Predict the Salivary Secretary Function in Patients With Head and Neck Squamous Carcinoma
por: Feng, Mei, et al.
Publicado: (2021)

The Value of Whole-Tumor Texture Analysis of ADC in Predicting the Early Recurrence of Locally Advanced Cervical Squamous Cell Cancer Treated With Concurrent Chemoradiotherapy
por: Zhang, Xiaomiao, et al.
Publicado: (2022)

Incremental prognostic value of ADC histogram analysis in patients with high-risk prostate cancer receiving adjuvant hormonal therapy after radical prostatectomy
por: He, Kangwen, et al.
Publicado: (2023)

CD47 Enhances Cell Viability and Migration Ability but Inhibits Apoptosis in Endometrial Carcinoma Cells via the PI3K/Akt/mTOR Signaling Pathway
por: Liu, Yun, et al.
Publicado: (2020)

TCR mimic compounds for pHLA targeting with high potency modalities in oncology
por: Gerber, Hans-Peter, et al.
Publicado: (2022)

CD47 on artificial structures
por: Schütz, Christian
Publicado: (2015)

The G4 Resolvase DHX36 Possesses a Prognosis Significance and Exerts Tumour Suppressing Function Through Multiple Causal Regulations in Non-Small Cell Lung Cancer
por: Cui, Yuxin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vm8epbhdopdt3svadvd0o3sdv4