Alcohol Impairs Immunometabolism and Promotes Naïve T Cell Differentiation to Pro-Inflammatory Th1 CD4(+) T Cells

CD4(+) T cell differentiation to pro-inflammatory and immunosuppressive subsets depends on immunometabolism. Pro-inflammatory CD4(+) subsets rely on glycolysis, while immunosuppressive Treg cells require functional mitochondria for their differentiation and function. Previous pre-clinical studies ha...

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Detalles Bibliográficos
Autores principales: McTernan, Patrick M., Levitt, Danielle E., Welsh, David A., Simon, Liz, Siggins, Robert W., Molina, Patricia E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133564/
https://www.ncbi.nlm.nih.gov/pubmed/35634279
http://dx.doi.org/10.3389/fimmu.2022.839390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133564/
https://www.ncbi.nlm.nih.gov/pubmed/35634279
http://dx.doi.org/10.3389/fimmu.2022.839390

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