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Alcohol Impairs Immunometabolism and Promotes Naïve T Cell Differentiation to Pro-Inflammatory Th1 CD4(+) T Cells

CD4(+) T cell differentiation to pro-inflammatory and immunosuppressive subsets depends on immunometabolism. Pro-inflammatory CD4(+) subsets rely on glycolysis, while immunosuppressive Treg cells require functional mitochondria for their differentiation and function. Previous pre-clinical studies ha...

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Detalles Bibliográficos
Autores principales:	McTernan, Patrick M., Levitt, Danielle E., Welsh, David A., Simon, Liz, Siggins, Robert W., Molina, Patricia E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133564/ https://www.ncbi.nlm.nih.gov/pubmed/35634279 http://dx.doi.org/10.3389/fimmu.2022.839390

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