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Reciprocal Regulation of Mitofusin 2-Mediated Mitophagy and Mitochondrial Fusion by Different PINK1 Phosphorylation Events

Mitochondrial repair is essential to metabolic homeostasis. Outer mitochondrial membrane mitofusin (MFN) proteins orchestrate mitochondrial fusion that opposes mitochondrial degeneration caused by senescence. Depending upon physiological context, MFN2 can either mediate mitochondrial fusion or recru...

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Detalles Bibliográficos
Autores principales: Li, Jiajia, Dang, Xiawei, Franco, Antonietta, Dorn, Gerald W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133611/
https://www.ncbi.nlm.nih.gov/pubmed/35646911
http://dx.doi.org/10.3389/fcell.2022.868465